How Can a Polymeric Formula Induce Remission in Crohn's Disease Patients?

被引：4

作者：

Boumessid, Kawthar ^{[1
]}

Barreau, Frederick ^{[1
]}

Mas, Emmanuel ^{[1
,2
]}

机构：

[1] Univ Toulouse, INSERM, INRAE, ENVT,UPS, F-31000 Toulouse, France

[2] CHU Toulouse, Hop Enfants, Unite Gastroenterol Hepatol Nutr Diabetol & Malad, F-31300 Toulouse, France

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 08期

关键词：

Crohn’ s disease; inflammatory bowel disease; exclusive enteral nutrition; mucosal healing; EXCLUSIVE ENTERAL NUTRITION; INFLAMMATORY-BOWEL-DISEASE; CHILDREN; THERAPY; DIET; CORTICOSTEROIDS; RESISTANCE; RESPONSES; EFFICACY; CELLS;

D O I：

10.3390/ijms22084025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Crohn's disease is an inflammatory bowel disease whose prevalence is increasing worldwide. Among medical strategies, dietary therapy with exclusive enteral nutrition is recommended as a first-line option, at least for children, because it induces clinical remission and mucosal healing. Modulen(R), a polymeric TGF-beta 2 enriched formula, has good palatability and is widely used. For the first time in the literature, this review outlines and discusses the clinical outcomes obtained with this therapy, as well as the potential mechanisms of action of its compounds. It can be explained by its TGF-beta 2 content, but also by its protein and lipid composition. Further well-designed studies are required to improve our knowledge and to optimize therapeutic strategies.

引用

页数：14

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