Experimental and theoretical studies of Palladium-hydrazide complexes' interaction with DNA and BSA, in vitro cytotoxicity activity and plasmid cleavage ability

被引：14
|
作者：
Karami, Kazem [1 ]
Jamshidian, Nasrin [1 ]
Zakariazadeh, Mostafa [2 ]
Momtazi-Borojeni, Amir Abbas [3 ,4 ,5 ]
Abdollahi, Elham [3 ,6 ]
Amirghofran, Zahra [7 ,8 ]
Shahpiri, Azar [9 ]
Nasab, Akram Kazemi [9 ]
机构：
[1] Isfahan Univ Technol, Dept Chem, Esfahan 8415683111, Iran
[2] Univ Tabriz, Res Inst Fundamental Sci RIFS, Tabriz, Iran
[3] FDA, Halal Res Ctr IRI, Tehran, Iran
[4] Mashhad Univ Med Sci, Nanotechnol Res Ctr, Bu Ali Res Inst, Mashhad, Razavi Khorasan, Iran
[5] Mashhad Univ Med Sci, Fac Med, Dept Med Biotechnol, Student Res Comm, Mashhad, Razavi Khorasan, Iran
[6] Mashhad Univ Med Sci, Fac Med, Dept Med Immunol, Student Res Comm, Mashhad, Razavi Khorasan, Iran
[7] Shiraz Univ Med Sci, Immunol Dept, Shiraz, Iran
[8] Shiraz Univ Med Sci, Autoimmune Dis Res Ctr, Shiraz, Iran
[9] Isfahan Univ Technol, Coll Agr, Dept Biotechnol, Esfahan 8415683111, Iran
来源：
COMPUTATIONAL BIOLOGY AND CHEMISTRY | 2021年 / 91卷
关键词：
Hydrazide; Palladium complexes; CT-DNA binding; BSA interaction; Plasmid cleavage; BOVINE SERUM-ALBUMIN; MOLECULAR DOCKING; BINDING INTERACTION; CRYSTAL-STRUCTURE; SELECTIVE CYTOTOXICITY; METHYLENE-BLUE; DRUG-BINDING; SCHIFF-BASE; SPECTROSCOPIC CHARACTERIZATION; POLYPYRIDYL COMPLEXES;
D O I：
10.1016/j.compbiolchem.2021.107435
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
New palladium complexes with general formula trans-[Pd(L)(2)(OAc)(2)] (1,2), (L = Benzhydrazide and 2-Furoic hydrazide) have been synthesized and characterized with various methods including elemental analysis, FTIR, (HNMR)-H-1 and mass spectroscopy. Afterward their interactions with bovine serum albumin and calf thymus deoxyribonucleic acid have been investigated by UV-vis absorption, fluorescence emission and circular dichroism spectroscopy. Also, site-selective replacement experiments with site probes have been carried out. Analysis of fluorescence spectrum indicated static quenching mechanism. Spectroscopic measurements for DNA binding showed the groove binding to DNA for both complexes. Furthermore, cytotoxicity studies of complexes and cis-platin have been done against colon carcinoma (CT26) and breast cancer (4T1) cell lines. Evaluation of complexes (1) and (2) on induction of apoptosis in CT26 cells has been done. Finally, plasmid cleavage ability of (1) and (2) was investigated by gel electrophoresis that indicate the more activity of (1) than (2).
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收藏
页数：19
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