Bubble Microreactors Triggered by an Alternating Magnetic Field as Diagnostic and Therapeutic Delivery Devices

被引：60
|
作者：
Yang, Fang [1 ,2 ,3 ]
Chen, Ping [1 ,2 ,3 ]
He, Wen [1 ,2 ,3 ]
Gu, Ning [1 ,2 ,3 ]
Zhang, Xizhi [1 ,2 ,3 ]
Fang, Kun [1 ,2 ,3 ]
Zhang, Yu [1 ,2 ,3 ]
Sun, JianFei [1 ,2 ,3 ]
Tong, Jiayi [4 ]
机构：
[1] Southeast Univ, Sch Biol Sci & Med Engn, Nanjing 210096, Peoples R China
[2] Jiangsu Key Lab Biomaterials & Devices, Nanjing 210009, Peoples R China
[3] State Key Lab Bioelect, Nanjing 210096, Peoples R China
[4] Southeast Univ, Zhongda Hosp, Dept Cardiol, Nanjing 210009, Peoples R China
来源：
SMALL | 2010年 / 6卷 / 12期
基金：
中国国家自然科学基金;
关键词：
diagnostics; drug delivery; magnetic materials; microreactors; nanoparticles; BIODEGRADABLE INTELLIGENT MATERIALS; POLYELECTROLYTE MICROCAPSULES; NANOPARTICLES; STIMULI; RELEASE; OSCILLATIONS; NANOSPHERES; METABOLISM; ULTRASOUND;
D O I：
10.1002/smll.201000173
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Microcontainers with embedded superparamagnetic nanoparticles can be changed into bubble microreactors upon treatment with an alternating magnetic field, which acts as a remote trigger for the release of encapsulated material. Exchange of an arginine solution inside and H2O2 solution outside the microcontainers generates NO gas. The microstructure combines ultrasound diagnostic and NO therapeutic functionalities. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1300 / 1305
页数：6
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