Methyl triterpenoates derived from oleanolic, ursolic, betulinic, glycyrrhetinic, platanic, or maslinic acid were converted into their corresponding sulfamates and carbamoylsulfamates. The sulfamates were screened in photometric sulforhodamine assays for cytotoxic activity employing several human tumor cell lines. Many of the compounds showed EC50 values in one-digit mu M concentration. Of special interest seems methyl (3 beta) 3-(aminosulfonyloxy)-11-oxo-oleanoate (18) showing good cytotoxicity for the human adenocarcinomic alveolar basal epithelial cell line A549 while being less toxic for non-malignant NIH 3T3 mouse fibroblasts.
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Pharm, Xian 710032, Peoples R China
Shenyang Pharmaceut Univ, Dept Phytochem, Shenyang, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Pharm, Xian 710032, Peoples R China
Tian, Ye
Tang, Hai-Feng
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Fourth Mil Med Univ, Xijing Hosp, Dept Pharm, Xian 710032, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Pharm, Xian 710032, Peoples R China
Tang, Hai-Feng
Qiu, Feng
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Shenyang Pharmaceut Univ, Dept Phytochem, Shenyang, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Pharm, Xian 710032, Peoples R China
Qiu, Feng
Wang, Xiao-Juan
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Fourth Mil Med Univ, Sch Stomatol, Dept Pharm, Xian 710032, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Pharm, Xian 710032, Peoples R China
Wang, Xiao-Juan
Chen, Xiao-Li
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Fourth Mil Med Univ, Xijing Hosp, Dept Pharm, Xian 710032, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Pharm, Xian 710032, Peoples R China
Chen, Xiao-Li
Wen, Ai-Dong
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Fourth Mil Med Univ, Xijing Hosp, Dept Pharm, Xian 710032, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Pharm, Xian 710032, Peoples R China
机构:
Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med 48, Shenyang 110016, Peoples R ChinaShenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med 48, Shenyang 110016, Peoples R China
Xu, Wei
Wu, Jia-Mei
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China Med Univ, Minist Publ Hlth, Key Lab Cell Biol, Dept Cell Biol, Shenyang 110001, Peoples R ChinaShenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med 48, Shenyang 110016, Peoples R China
Wu, Jia-Mei
Zhu, Zheng
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Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med 48, Shenyang 110016, Peoples R ChinaShenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med 48, Shenyang 110016, Peoples R China
Zhu, Zheng
Sha, Yi
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Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med 48, Shenyang 110016, Peoples R ChinaShenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med 48, Shenyang 110016, Peoples R China
Sha, Yi
Fang, Jin
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China Med Univ, Minist Publ Hlth, Key Lab Cell Biol, Dept Cell Biol, Shenyang 110001, Peoples R ChinaShenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med 48, Shenyang 110016, Peoples R China
Fang, Jin
Li, Yu-Shan
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Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med 48, Shenyang 110016, Peoples R ChinaShenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med 48, Shenyang 110016, Peoples R China