Spectrum of cytokine gene expression in intestinal mucosal lesions of Crohn's disease and ulcerative colitis

被引：51
|
作者：
Funakoshi, K [1 ]
Sugimura, K [1 ]
Anezaki, K [1 ]
Bannai, H [1 ]
Ishizuka, K [1 ]
Asakura, H [1 ]
机构：
[1] Niigata Univ, Sch Med, Dept Internal Med 3, Niigata 951, Japan
来源：
DIGESTION | 1998年 / 59卷 / 01期
关键词：
Crohn's disease; ulcerative colitis; cytokine mRNA; reverse transcription-polymerase chain reaction;
D O I：
10.1159/000007470
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Background/Aims: We investigated the mRNA expression of spectrum of cytokines in the colonic mucosa in inflammatory bowel disease (IBD). Methods: The expression of cytokine gene was evaluated by using the reverse transcription-polymerase chain reaction and the radioactivity of amplified cDNA standardized by coamplified beta-actin cDNA. Results: Crohn's disease and ulcerative colitis showed significantly increased expression of IL-1 beta, IL-6, IL-8 and TNF-alpha mRNA as compared with controls (p < 0.05). Conclusion: Proinflammatory cytokines such as IL-1 beta, IL-6, IL-8 and TNF-alpha are closely involved in the immune abnormalities of inflammatory mucosal lesions in IBD.
引用
收藏
页码：73 / 78
页数：6
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