Red pepper seed water extract suppresses high-fat diet-induced obesity in C57BL/6 mice

被引：8
|
作者：
Kim, Hwa-Jin [1 ]
You, Mi-Kyoung [2 ]
Wang, Ziyun [3 ]
Lee, Young-Hyeon [3 ]
Kim, Hyeon-A [3 ]
机构：
[1] Hisol Inc, Namwon Si, Jeollabuk Do, South Korea
[2] Univ Nebraska, Dept Nutr & Hlth Sci, Lincoln, NE USA
[3] Mokpo Natl Univ, Dept Food & Nutr, Muan Gun, Jeollanam Do, South Korea
来源：
FOOD SCIENCE AND BIOTECHNOLOGY | 2020年 / 29卷 / 02期
关键词：
Red pepper seed; Anti-obesity; High-fat diet; HOMA-IR; Lipid metabolism; ADIPOGENESIS; CAPSAICIN; INSULIN;
D O I：
10.1007/s10068-019-00710-9
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
In this study, the protective effect of red pepper seed water extract (RPS) against the obesity in high fat diet (HFD)-fed mice was investigated (HFD control group, and HFD group treated with 100 or 200 mg/kg body weight of RPS for 13 weeks). The application of RPS partially reversed the HFD-induced increases in body weight and adipose tissue weight. The patterns of the adipose tissue weights were parallel to the patterns of fat area, as measured in DXA procedure. In the adipose tissue, RPS suppressed the expression of adipogenic transcription factors and adipose marker genes. AMP-activated protein kinase activation was observed in the adipose tissue by RPS treatment. In addition, RPS improved high homeostasis model assessment of insulin resistance and hyperlipidemia in HFD fed mice. These findings suggest that RPS can be used as a potential therapeutic substance for reducing body fat and obesity related diseases.
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页码：275 / 281
页数：7
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