Iridium-Catalyzed Direct Reductive Amination of Ketones and Secondary Amines: Breaking the Aliphatic Wall

被引：0
|
作者：
Jouffroy, Matthieu [1 ]
Nguyen, Thi-Mo
Cordier, Marie
Blot, Marielle
Roisnel, Thierry
Gramage-Doria, Rafael [2 ]
机构：
[1] Janssen Pharmaceut NV, Discovery Proc Res, Beerse, Belgium
[2] Univ Rennes, Rennes, France
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2022年 / 28卷 / 36期
关键词：
amines; high-throughput experimentation; hydrogenation; iridium; ketones; reductive amination;
D O I：
10.1002/chem.202201592
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Invited for the cover of this issue are Matthieu Jouffroy from Discovery Process Research at Janssen Pharmaceutica N.V. and the group of Rafael Gramage-Doria at the University of Rennes. The image depicts an Ir-based catalytic system "fueled" by hydrogen for the direct reductive amination of ketones and secondary amines, allowing complex aliphatic tertiary amines to be prepared and, so, new chemical space to be reached. Read the full text of the article at 10.1002/chem.202201078.
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