Long Non-coding RNAs Function as Competing Endogenous RNAs to Regulate Cancer Progression

被引：0

作者：

Lian Yu ^{[1
,2
,3
,4
,5
]}

Li Xia-Yu ^{[5
]}

Tang Yan-Yan ^{[3
,4
]}

Yang Li-Ting ^{[3
,4
]}

Li Xiao-Ling ^{[1
,2
,3
,4
,5
]}

Xiong Wei ^{[1
,2
,3
,4
,5
]}

Li Gui-Yuan ^{[1
,2
,3
,4
,5
]}

Zeng Zhao-Yang ^{[1
,2
,3
,4
,5
]}

机构：

[1] Cent S Univ, Hunan Canc Hosp, Hunan Key Lab Translat Radiat Oncol, Changsha 410013, Hunan, Peoples R China

[2] Cent S Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China

[3] Cent S Univ, Key Lab Carcinogenesis, Minist Hlth, Canc Res Inst, Changsha 410078, Hunan, Peoples R China

[4] Cent S Univ, Key Lab Carcinogenesis & Canc Invas, Minist Educ, Canc Res Inst, Changsha 410078, Hunan, Peoples R China

[5] Cent S Univ, Xiangya Hosp 3, Dis Genome Res Ctr, Hunan Key Lab Nonresolving Inflammat & Canc, Changsha 410013, Hunan, Peoples R China

来源：

PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2016年 / 43卷 / 03期

基金：

中国国家自然科学基金;

关键词：

long non-coding RNAs (lncRNA); microRNA(miRNAs); tumorigenesis; NASOPHARYNGEAL CARCINOMA; MESENCHYMAL TRANSITION; CELL-PROLIFERATION; HEPATOCELLULAR-CARCINOMA; TUMOR-SUPPRESSOR; MIRNA SPONGES; EXPRESSION; METASTASIS; CERNA; TARGET;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long non-coding RNAs are defined as endogenous molecules With a length greater than 200 nucleotides and with no apparent coding potential. Recent studies showed that lncRNA could interact with the miRNA as a competing endogenous RNAs (ceRNAs) to participate in the expression regulation of target genes, which exert an importance role in the initiation and progression of tumor. In this review, based on lncRNA functioning as ceRNAs, we described the mechanism and function of some relevant lncRNA in the initiation and progression of tumor. A growing number of researches indicated that the interaction between lncRNA and miRNA in tumor genesis would provide new ideas in tumor diagnosis and treatment.

引用

页码：219 / 225

页数：7

共 68 条

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