Curcumin Induces p53-Null Hepatoma Cell Line Hep3B Apoptosis through the AKT-PTEN-FOXO4 Pathway

被引：24
|
作者：
Liou, An-Ting [1 ]
Chen, Mei-Fang [2 ]
Yang, Chu-Wen [1 ]
机构：
[1] Soochow Univ, Dept Microbiol, Taipei 111, Taiwan
[2] Taipei Vet Gen Hosp, Dept Med Res, Taipei 112, Taiwan
来源：
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2017年 / 2017卷
关键词：
CANCER CELLS; DOWN-REGULATION; UP-REGULATION; CYCLE ARREST; CARCINOMA; PROLIFERATION; EPIDEMIOLOGY; INHIBITION; MODULATION; P53;
D O I：
10.1155/2017/4063865
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Objective. Curcumin (diferuloylmethane) is a yellow-colored polyphenol with antiproliferative and proapoptotic activities to various types of cancer cells. This study explored the mechanism by which curcumin induces p53-null hepatoma cell apoptosis. Results. AKT, FOXO1, and FOXO3 proteins were downregulated after curcumin treatment. Conversely, PTEN was upregulated. Subcellular fractionations revealed that the FOXO4 protein translocated from cytosol into the nucleus after curcumin treatment. Overexpression of FOXO4 increases the sensitivity of Hep3B cells to curcumin. Knockdown of the FOXO4 gene by siRNA inhibits the proapoptotic effects of curcumin on Hep3B cell. Conclusions. This study revealed the AKT/PTEN/FOXO4 pathway as a potential candidate of target for treatment of p53-null liver cancers.
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页数：12
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