Roles of galectin-3 in metabolic disorders and tumor cell metabolism

被引：43

作者：

Li, Ying-Shuang ^{[1
]}

Li, Xiao-Tong ^{[1
]}

Yu, Lu-Gang ^{[2
]}

Wang, Lei ^{[1
]}

Shi, Zhao-Yu ^{[1
]}

Guo, Xiu-Li ^{[1
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Dept Pharmacol,Key Lab Chem Biol, Jinan 250012, Peoples R China

[2] Univ Liverpool, Inst Translat Med, Dept Gastroenterol, Liverpool L69 3GE, Merseyside, England

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2020年 / 142卷

关键词：

Galectin-3; Metabolic disorders; Tumor metabolism; GLYCATION END-PRODUCTS; DIET-INDUCED OBESITY; ADIPOSE-TISSUE; EXTRACELLULAR GALECTIN-3; MOLECULAR-MECHANISM; SIGNALING PATHWAYS; INSULIN-RESISTANCE; CANCER; INFLAMMATION; INHIBITION;

D O I：

10.1016/j.ijbiomac.2019.09.118

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The galactoside-binding protein galectin-3 is commonly overexpressed by cancer cells and promotes cancer progression and metastasis. Over the past few years, evidence has emerged that galectin-3 is also overexpressed in several metabolic malfunction conditions such as diabetes, obesity and atherosclerosis and is involved in the regulation of the occurrence and development of these diseases. Recently, Galectin-3 expression is shown also to be associated with glycolysis and mitochondrial metabolism in tumors, and promotes tumor metabolic reprogramming for their adaption to the microenvironment stress imposed by oxygen and nutrients deprivation. This brief review summarizes the current understanding of the roles and actions of galectin-3 in these metabolic diseases and in tumor metabolism. (C) 2019 Elsevier B.V. All rights reserved.

引用

页码：463 / 473

页数：11

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