Enantioselective synthesis of the key intermediate of the acyl-CoA:: Cholesterol acyltransferase (ACAT) inhibitor (R-106578) using 2,2′-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP)-Ru(OAc)2 as a catalyst

被引：0

作者：

Murakami, M ^{[1
]}

Kobayashi, K ^{[1
]}

Hirai, K ^{[1
]}

机构：

[1] Sankyo Co Ltd, Proc Dev Labs, Hiratsuka, Kanagawa 2548560, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2000年 / 48卷 / 10期

关键词：

enantioselective hydrogenation; (R)-BINAP-Ru(OAc)(2); coumarin derivative; ACAT inhibitor;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Acidic segment of an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor, R-106578 was synthesized by enantioselective hydrogenation of the Z-olefine (9-(Z)) using (R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP)-Ru(OAc)(2) as a catalyst in methanol at 100 degrees C, 5 kgf/cm(2) of H-2 pressure. The requisite Z-olefine was prepared regioselectively via coumarin derivative (5).

引用

页码：1567 / 1569

页数：3

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