Design and synthesis of a series highly potent and bioavailable FASN KR domain inhibitors for cancer

被引：3

作者：

Lu, Tianbao ^{[1
]}

Alexander, Richard ^{[1
]}

Bignan, Gilles ^{[1
]}

Bischoff, James ^{[1
]}

Connolly, Peter ^{[1
]}

Cummings, Max ^{[1
]}

De Breucker, Sabine ^{[2
]}

Esser, Norbert ^{[2
]}

Fraiponts, Erwin ^{[2
]}

Gilissen, Ron ^{[2
]}

Grasberger, Bruce ^{[1
]}

Janssens, Boudewijn ^{[2
]}

Ludovici, Donald ^{[1
]}

Meerpoel, Lieven ^{[2
]}

Meyer, Christophe ^{[3
]}

Parker, Michael ^{[1
]}

Peeters, Danielle ^{[2
]}

Schubert, Carsten ^{[1
]}

Smans, Karine ^{[2
]}

Van Nuffel, Luc ^{[2
]}

Vermeulen, Peter ^{[2
]}

机构：

[1] Janssen Res & Dev LLC, Spring House, PA USA

[2] Janssen Res & Dev LLC, Beerse, Belgium

[3] Janssen Res & Dev LLC, Val De Reuil, France

来源：

CANCER RESEARCH | 2014年 / 74卷 / 19期

关键词：

D O I：

10.1158/1538-7445.AM2014-4747

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

4747

引用

页数：2

共 50 条

[1] Design and structure activity relationships of highly potent and bioavailable imidazolinone FASN KR domain inhibitors
Bignan, G.
Alexander, R.
Bischoff, J.
Connolly, P.
Cummings, M.
De Breucker, S.
Esser, N.
Fraiponts, E.
Gilissen, R.
Grasberger, B.
Janssens, B.
Lu, T.
Ludovici, D.
Meerpoel, L.
Meyer, C.
Parker, M.
Peeters, D.
Rocaboy, C.
Schubert, C.
Smans, K.
EUROPEAN JOURNAL OF CANCER, 2014, 50 : 141 - 142
[2] Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy
Lu, Tianbao
Schubert, Carsten
Cummings, Maxwell D.
Bignan, Gilles
Connolly, Peter J.
Smans, Karine
Ludovici, Donald
Parker, Michael H.
Meyer, Christophe
Rocaboy, Christian
Alexander, Richard
Grasberger, Bruce
De Breucker, Sabine
Esser, Norbert
Fraiponts, Erwin
Gilissen, Ron
Janssens, Boudewijn
Peeters, Danielle
Van Nuffel, Luc
Vermeulen, Peter
Bischoff, James
Meerpoel, Lieven
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (12) : 2159 - 2164
[3] DESIGN AND SYNTHESIS OF POTENT, ORALLY BIOAVAILABLE HIV-1 PROTEASE INHIBITORS
KALDOR, SW
KALISH, V
DRESSMAN, BA
FRITZ, JE
HAMMOND, M
CROWELL, TA
TATLOCK, J
REICH, S
DAVIES, J
APPELT, K
SHETTY, B
SU, KS
CAMPANALE, KM
BURGESS, JA
LUBBENHUSEN, PP
BAXTER, AJ
MUESING, MA
HATCH, SD
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 208 : 17 - MEDI
[4] Rational design and synthesis of highly potent β-glucocerebrosidase inhibitors
Zhu, XX
Sheth, KA
Li, SH
Chang, HH
Fan, JQ
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (45) : 7450 - 7453
[5] DESIGN AND SYNTHESIS OF POTENT AND HIGHLY SELECTIVE THROMBIN INHIBITORS
HILPERT, K
ACKERMANN, J
BANNER, DW
GAST, A
GUBERNATOR, K
HADVARY, P
LABLER, L
MULLER, K
SCHMID, G
TSCHOPP, TB
VANDEWATERBEEMD, H
JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (23) : 3889 - 3901
[6] Optimization of a series of potent, selective and orally bioavailable SYK inhibitors
Grimster, Neil P.
Gingipalli, Lakshmaiah
Barlaam, Bernard
Su, Qibin
Zheng, XiaoLan
Watson, David
Wang, Haixia
Simpson, Iain
Pike, Andy
Balazs, Amber
Boiko, Scott
Ikeda, Timothy P.
Impastato, Anna C.
Jones, Natalie H.
Kawatkar, Sameer
Kemmitt, Paul
Lamont, Scott
Patel, Joe
Read, Jon
Sarkar, Ujjal
Sha, Li
Tomlinson, Ronald C.
Wang, Haiyun
Wilson, David M.
Zehnder, Troy E.
Wang, Lianghe
Wang, Peng
Goldberg, Frederick W.
Shao, Wenlin
Fawell, Stephen
Dry, Hannah
Dowling, James E.
Edmondson, Scott D.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 30 (19)
[7] Design and Preparation of Potent, Nonpeptidic, Bioavailable Renin Inhibitors
Bezencon, Olivier
Bur, Daniel
Weller, Thomas
Richard-Bildstein, Sylvia
Remen, Lubos
Sifferlen, Thierry
Corminboeuf, Olivier
Grisostomi, Corinna
Boss, Christoph
Prade, Lars
Delahaye, Stephane
Treiber, Alexander
Strickner, Panja
Binkert, Christoph
Hess, Patrick
Steiner, Beat
Fischli, Walter
JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (12) : 3689 - 3702
[8] Discovery of a novel, highly potent and orally bioavailable pyrrolidinone indole series of irreversible Myeloperoxidase (MPO) inhibitors
Regard, Jean B.
Harrison, Tyler J.
Axford, Jake
Axford, Laura
Lee, Lac
Ren, Xianglin
Deng, Lin
Reynolds, Aimee
Mao, Justin
Liu, Qian
Patnaik, Anup
Cohick, Evan
Hollis-Symynkywicz, Micah
Loi, Sally
Riek, Simone
McKeever, Una
Dunstan, David
Sung, MooJe
Ware, Nathaniel F.
Brown, Alan P.
Hamann, Lawrence G.
Marcinkeviciene, Jovita
Patterson, Andrew W.
Marro, Martin L.
BIOCHEMICAL PHARMACOLOGY, 2023, 209
[9] Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors
Barlaam, Bernard
Cadogan, Elaine
Campbell, Andrew
Colclough, Nicola
Dishington, Allan
Durant, Stephen
Goldberg, Kristin
Hassall, Lorraine A.
Hughes, Gareth D.
MacFaul, Philip A.
McGuire, Thomas M.
Pass, Martin
Patel, Anil
Pearson, Stuart
Petersen, Jens
Pike, Kurt G.
Robb, Graeme
Stratton, Natalie
Xin, Guohong
Zhai, Baochang
ACS MEDICINAL CHEMISTRY LETTERS, 2018, 9 (08): : 809 - 814
[10] Design and synthesis of potent, selective, and orally bioavailable macrocyclic TF-FVIIa inhibitors
Zhang, Xiaojun
Jiang, Wen
Jacutin-Porte, Swanee
Glunz, Peter W.
Ladziata, Vladimir
Zou, Yan
Cheng, Xuhong
Nirschl, Alexandra H.
Johnson, James A.
Philips, Monique
Wurtz, Nicholas R.
Parkhurst, Brandon L.
Delucca, Indawati
Luettgen, Joseph M.
Knabb, Robert
Rendina, Alan R.
Harper, Timothy M.
Wei, Anzhi
Mueller, Luciano
Cheney, Daniel L.
Seiffert, Dietmar
Wong, Pancras C.
Wexler, Ruth R.
Priestley, Scott
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245

← 1 2 3 4 5 →