Candida rugosa lipase-mediated enantioselective acetylation studies on (±)-3-arylmethyl-3-hydroxymethyl-2,3-dihydro-1-benzopyran-4(H)-ones

被引：0
|
作者：
Trikha, S
Kumar, R
Dhawan, A
Poonam
Prasad, AK
Cholli, AL
Olsen, CE
Watterson, AC
Parmar, VS [1 ]
机构：
[1] Univ Delhi, Dept Chem, Bioorgan Lab, Delhi 110007, India
[2] Univ Massachusetts, Dept Chem, Inst Nano Sci & Engn Technol, Lowell, MA 01854 USA
[3] Royal Vet & Agr Univ, Dept Chem, DK-1871 Copenhagen, Denmark
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2005年 / 44卷 / 02期
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D O I：
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Candida rugosa lipase, catalyzed enantioselective acetylation reactions have been performed on novel (+/-)-3-arylmethyl-3-hydroxymethyl-2,3-dihydrobenzopyran-4-ones in diisopropyl ether. The Candida rugosa lipase-catalyzed acetylations exhibit the enantiomeric separation of the racemic compounds 5a-g, the enantioselectivity of the reaction has been found to be highly dependent on the structure of the substrate. The enantiomeric excess (ee) values are determined by H-1 NMR spectral analysis of their O-acetylmandelic acid esters and highest enantiomeric excess obtained is 79% in case of 5c.
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页码：356 / 365
页数：10
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