Safety, Efficacy, and Pharmacokinetics of AMG 510, a Novel KRASG12C Inhibitor, in Patients with Non-Small Cell Lung Cancer

被引：0
|
作者：
Govindan, R. [1 ]
Fakih, M. [2 ]
Price, T. [3 ]
Falchook, G. [4 ]
Desai, J. [5 ]
Kuo, J. [6 ]
Strickler, J. [7 ]
Krauss, J. [8 ]
Li, B. [9 ]
Denlinger, C. [10 ]
Durm, G. [11 ]
Ngang, J. [12 ]
Henary, H. [12 ]
Ngarmchamnanrith, G. [12 ]
Rasmussen, E. [12 ]
Morrow, P. K. [12 ]
Hong, D. [13 ]
机构：
[1] Washington Univ, Sch Med, Alvin J Siteman Canc Ctr, St Louis, MO USA
[2] City Hope Natl Med Ctr, Duarte, CA USA
[3] Queen Elizabeth Hosp, Woodville South, Australia
[4] HealthONE, Sarah Cannon Res Inst, Denver, CO USA
[5] Peter MacCallum Canc Ctr, Melbourne, Vic, Australia
[6] Scientia Clin Res, Randwick, NSW, Australia
[7] Duke Univ, Med Ctr, Durham, NC 27706 USA
[8] Univ Michigan, Ann Arbor, MI 48109 USA
[9] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA
[10] Fox Chase Canc Ctr, 7701 Burholme Ave, Philadelphia, PA 19111 USA
[11] Indiana Univ, Simon Canc Ctr, Indianapolis, IN 46204 USA
[12] Amgen Inc, Thousand Oaks, CA 91320 USA
[13] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
来源：
JOURNAL OF THORACIC ONCOLOGY | 2019年 / 14卷 / 11期
关键词：
AMG; 510; lung cancer; KRAS G12C; NSCLC;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
OA01.06
引用
收藏
页码：S1125 / S1126
页数：2
相关论文
共 50 条
  • [41] Targeting KRASG12C in Non-Small-Cell Lung Cancer: Current Standards and Developments
    Torres-Jimenez, Javier
    Espinar, Javier Baena
    de Cabo, Helena Bote
    Berjaga, Maria Zurera
    Esteban-Villarrubia, Jorge
    Fraile, Jon Zugazagoitia
    Paz-Ares, Luis
    DRUGS, 2024, 84 (05) : 527 - 548
  • [42] Adagrasib: a novel inhibitor for KRASG12C-mutated non-small-cell lung cancer
    Guo, Matthew Z.
    Marrone, Kristen A.
    Spira, Alexander
    Rosner, Samuel
    FUTURE ONCOLOGY, 2023, 19 (15) : 1037 - 1051
  • [43] The Prevalence and Concurrent Pathogenic Mutations of KRASG12C in Northeast Chinese Non-small-cell Lung Cancer Patients
    Liu, Yan
    Li, Hui
    Zhu, Jing
    Zhang, Yang
    Liu, Xianhong
    Li, Rixin
    Zhang, Qiang
    Cheng, Ying
    CANCER MANAGEMENT AND RESEARCH, 2021, 13 : 2447 - 2454
  • [44] Adagrasib in KRYSTAL-12 has Broken the KRASG12C Enigma Code in Non-Small Cell Lung Carcinoma
    Luo, Faustine X.
    Arter, Zhaohui Liao
    LUNG CANCER-TARGETS AND THERAPY, 2024, 15 : 161 - 167
  • [45] Synergistic enhancement of KRASG12C inhibitor adagrasib by AMD1 inhibitor SAM486 in non-small cell lung cancer: in vitro and in vivo studies
    Lopez-Munoz, R.
    Martin-Martin, A.
    Buelvas, N.
    Guzman-Kunstmann, S.
    Chipon, C.
    EUROPEAN JOURNAL OF CANCER, 2024, 211 : S87 - S87
  • [46] A phase 1 clinical trial to evaluate safety, tolerability, pharmacokinetics (PK) and efficacy of D-1553, a novel KRASG12C inhibitor, in patients with advanced or metastatic solid tumor harboring KRASG12C mutation.
    Price, Timothy
    Grewal, Jaspreet
    Abed, Afaf
    Moore, Melissa
    Yeh, Yu-Min
    Gadgeel, Shirish
    Richardson, Gary
    Underhill, Craig
    Ganju, Vinod
    Lee, Keun-Wook
    Huh, Seok Jae
    Kim, Sang-We
    Yang, Chih-Hsin
    Chen, Yuh-Min
    Xiang, Ziyong
    Shi, Zhe
    Wang, Yaolin
    Zhang, Ling
    Millward, Michael
    CANCER RESEARCH, 2022, 82 (12)
  • [47] Immune checkpoint inhibitor efficacy and safety in elderly non-small cell lung cancer patients
    Kubo, T.
    Watanabe, H.
    Ninomiya, K.
    Kudo, K.
    Minami, D.
    Murakami, E.
    Ochi, N.
    Ninomiya, T.
    Harada, D.
    Yasugi, M.
    Ichihara, E.
    Ohashi, K.
    Fujiwara, K.
    Hotta, K.
    Tabata, M.
    Maeda, Y.
    Kiura, K.
    ANNALS OF ONCOLOGY, 2018, 29
  • [48] Immune checkpoint inhibitor efficacy and safety in older non-small cell lung cancer patients
    Kubo, Toshio
    Watanabe, Hiromi
    Ninomiya, Kiichiro
    Kudo, Kenichiro
    Minami, Daisuke
    Murakami, Etsuko
    Ochi, Nobuaki
    Ninomiya, Takashi
    Harada, Daijiro
    Yasugi, Masayuki
    Ichihara, Eiki
    Ohashi, Kadoaki
    Rai, Kammei
    Fujiwara, Keiichi
    Hotta, Katsuyuki
    Tabata, Masahiro
    Maeda, Yoshinobu
    Kiura, Katsuyuki
    JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2020, 50 (12) : 1447 - 1453
  • [49] SOTORASIB IS ACTIVE IN KRASG12C-MUTANT NON-SMALL CELL LUNG CANCER
    Skoulidis, F.
    Li, B. T.
    Dy, G. K.
    Price, T. J.
    Falchook, G. S.
    Wolf, J.
    CANCER DISCOVERY, 2021, 11 (08) : 1870 - 1870
  • [50] KRAS Inhibitor Resistance in MET-Amplified KRASG12C Non-Small Cell Lung Cancer Induced By RAS- and Non-RAS-Mediated Cell Signaling Mechanisms
    Suzuki, Shinichiro
    Yonesaka, Kimio
    Teramura, Takeshi
    Takehara, Toshiyuki
    Kato, Ryoji
    Sakai, Hitomi
    Haratani, Koji
    Tanizaki, Junko
    Kawakami, Hisato
    Hayashi, Hidetoshi
    Sakai, Kazuko
    Nishio, Kazuto
    Nakagawa, Kazuhiko
    CLINICAL CANCER RESEARCH, 2021, 27 (20) : 5697 - 5707
12345