Serum MUC5AC mucin as a potential marker for cholangiocarcinoma

被引：36

作者：

Wongkham, S ^{[1
]}

Sheehan, JK

Boonla, C

Patrakitkomjorn, S

Howard, M

Kirkham, S

Sripa, B

Wongkham, C

Bhudhisawasdi, V

机构：

[1] Khon Kaen Univ, Fac Med, Dept Biochem, Khon Kaen 40002, Thailand

[2] Khon Kaen Univ, Liver Fluke & Cholangiocarcinoma Res Ctr, Khon Kaen 40002, Thailand

[3] Univ N Carolina, Cyst Fibrosis Ctr, Chapel Hill, NC USA

[4] Khon Kaen Univ, Dept Clin Chem, Fac Associated Med Sci, Khon Kaen, Thailand

[5] Univ Manchester, Wellcome Trust Ctr Cell Matrix Res, Sch Biol Sci, Manchester, Lancs, England

[6] Khon Kaen Univ, Fac Med, Dept Pathol, Khon Kaen 40002, Thailand

[7] Khon Kaen Univ, Fac Med, Dept Surg, Khon Kaen 40002, Thailand

来源：

CANCER LETTERS | 2003年 / 195卷 / 01期

关键词：

cholangiocarcinoma; mucin; MUC5AC; tumor marker; bile duct;

D O I：

10.1016/S0304-3835(02)00691-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aberrant expression of MUC5AC mucin is obvious in cholangiocarcinoma tissues, however, this mucin has never been detected in the serum. Using immunoblotting marked with antibody vs. MUC5AC core protein, we could detect MUC5AC mucin in the serum of 112 from 179 cholangiocarcinoma patients (62.6% sensitivity), two of the 62 with benign hepatobiliary diseases, six of the 60 with hepato-gastrointestinal cancer, and none in either the 60 active opisthorchiasis or 74 healthy persons. Detection of serum mucin in the serum of cholangiocarcinorna patients corresponded well to the MUC5AC expressed in individual tissues. Serum MUC5AC may be used to enhance the diagnostic accuracy of cholangiocarcinoma. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：93 / 99

页数：7

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