Classification of GABAergic interneurons by leading neuroscientists

被引:12
|
作者
Mihaljevic, Bojan [1 ]
Benavides-Piccione, Ruth [2 ,3 ]
Bielza, Concha [1 ]
Larranaga, Pedro [1 ]
DeFelipe, Javier [2 ,3 ]
机构
[1] Univ Politecn Madrid, Dept Inteligencia Artificial, Computat Intelligence Grp, Boadilla Del Monte 28660, Spain
[2] Univ Politecn Madrid, Lab Cajal Circuitos Cort, Pozuelo De Alarcon 28223, Spain
[3] CSIC, Inst Cajal, Pozuelo De Alarcon 28223, Spain
基金
欧盟地平线“2020”;
关键词
NOMENCLATURE;
D O I
10.1038/s41597-019-0246-8
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
There is currently no unique catalog of cortical GABAergic interneuron types. In 2013, we asked 48 leading neuroscientists to classify 320 interneurons by inspecting images of their morphology. That study was the first to quantify the degree of agreement among neuroscientists in morphology-based interneuron classification, showing high agreement for the chandelier and Martinotti types, yet low agreement for most of the remaining types considered. Here we present the dataset containing the classification choices by the neuroscientists according to interneuron type as well as to five prominent morphological features. These data can be used as crisp or soft training labels for learning supervised machine learning interneuron classifiers, while further analyses can try to pinpoint anatomical characteristics that make an interneuron especially difficult or especially easy to classify.
引用
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页数:6
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