Enantioselective Construction of Quaternary Carbon Stereocenter via Palladium-Catalyzed Asymmetric Allylic Alkylation of Lactones

被引：23
|
作者：
Li, Xiao-Hui [1 ]
Wan, Shi-Li [1 ]
Chen, Di [1 ]
Liu, Qing Rong [1 ]
Ding, Chang-Hua [1 ]
Fang, Ping [1 ]
Hou, Xue-Long [1 ,2 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai Hong Kong Joint Lab Chem Synth, 345 Lingling Rd, Shanghai 200032, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2016年 / 48卷 / 10期
基金：
中国国家自然科学基金;
关键词：
palladium; allylic alkylation; asymmetric catalysis; lactones; quaternarycarbon; KINETIC RESOLUTION; ACYCLIC KETONES; ALLYLATION; REGIO; SUBSTITUTION; LIGANDS; AMINATION; DIASTEREO; ESTERS;
D O I：
10.1055/s-0035-1561574
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and practical method for the synthesis of ,-disubstituted six-membered lactones was developed. Enantioselective construction of quaternary carbon centers by utilizing Pd-catalyzed asymmetric allylic alkylation proved its feasibility.
引用
收藏
页码：1568 / 1572
页数：5
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