Pyridine-based, microwave-assisted one-pot synthetic protocol for the synthesis of ethyl 3-substituted-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates

被引：1
|
作者：
Mundra, Sourabh [1 ]
Mahesh, Radhakrishnan [1 ]
机构：
[1] Birla Inst Technol & Sci, Dept Pharm, FD-3, Pilani 333031, Rajasthan, India
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 2016年 / 42卷 / 05期
关键词：
5-Carboethoxy-2-thiouracil; Thiourea; Pyrimidine; Microwave irradiation; Synthesis; DIASTEREOSELECTIVE SYNTHESIS; CONDENSATION REACTION; EFFICIENT SYNTHESIS; THERMAL-BEHAVIOR; PTC ALKYLATION; COMPLEXES; DERIVATIVES; ISOOROTATE; PALLADIUM; TRIFLATE;
D O I：
10.1007/s11164-015-2270-4
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Pyridine has been used for one-pot, two-component synthesis of ethyl 3-substituted-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives in moderate to good yields by condensing N-substituted thioureas with diethyl ethoxymalonate under microwave irradiation.
引用
收藏
页码：4207 / 4219
页数：13
相关论文
共 50 条
  • [31] Ethyl 4-(4-chlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
    Nayak, Susanta K.
    Venugopala, K. N.
    Chopra, Deepak
    Govender, Thavendran
    Kruger, Hendrik G.
    Maguire, Glenn E. M.
    Row, T. N. Guru
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O2518 - +
  • [32] Ethyl 4-(4-cyanophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
    Wu, De-Hong
    Zhang, You-Hong
    Li, Zhu-Feng
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O1733 - U1883
  • [33] Microwave-assisted synthesis, molecular docking and antitubercular activity of 1,2,3,4-tetrahydropyrimidine-5-carbonitrile derivatives
    Mohan, Sahoo Biswa
    Kumar, B. V. V. Ravi
    Dinda, S. C.
    Naik, D.
    Seenivasan, S. Prabu
    Kumar, Vanaja
    Rana, Dharmarajsinh N.
    Brahmkshatriya, Pathik S.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (24) : 7539 - 7542
  • [34] Synthesis, structure-activity relationship of novel substituted 4H-chromen-1,2,3,4-tetrahydropyrimidine-5-carboxylates as potential anti-mycobacterial and anticancer agents
    Raju, B. China
    Rao, R. Nageswara
    Suman, P.
    Yogeeswari, P.
    Sriram, D.
    Shaik, Thokhir Basha
    Kalivendi, Shasi Vardhan
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (10) : 2855 - 2859
  • [35] Microwave-assisted one-pot synthesis of 2,3-disubstituted 3H-quinazolin-4-ones
    Liu, JF
    Lee, JY
    Dalton, AM
    Bi, G
    Yu, LB
    Baldino, CM
    McElory, E
    Brown, M
    TETRAHEDRON LETTERS, 2005, 46 (08) : 1241 - 1244
  • [36] Nano-Co3O4-catalyzed microwave-assisted one-pot synthesis of some seleno [2 , 3-b ] pyridine/quinoline derivatives
    Yasser Attia Attia
    Shams H. Abdel-Hafez
    Research on Chemical Intermediates, 2021, 47 : 3719 - 3732
  • [37] Microwave-Assisted Synthesis of Some Novel 1,2,3,4-Tetrahydropyrimidine Derivatives as Antidiabetic Agents
    M. D. Vachhani
    J. N. Lalpara
    S. D. Hadiyal
    G. G. Dubal
    Russian Journal of Organic Chemistry, 2022, 58 : 356 - 362
  • [38] Nano-Co3O4-catalyzed microwave-assisted one-pot synthesis of some seleno [2, 3-b ] pyridine/quinoline derivatives
    Attia, Yasser Attia
    Abdel-Hafez, Shams H.
    RESEARCH ON CHEMICAL INTERMEDIATES, 2021, 47 (09) : 3719 - 3732
  • [39] Microwave-Assisted Synthesis of Some Novel 1,2,3,4-Tetrahydropyrimidine Derivatives as Antidiabetic Agents
    Vachhani, M. D.
    Lalpara, J. N.
    Hadiyal, S. D.
    Dubal, G. G.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2022, 58 (03) : 356 - 362
  • [40] Synthesis and Hypotensive Activity of Novel Styryl Derivatives Based on Ethyl-4-(4-Methoxyphenyl)-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
    S. D. Fazylov
    O. A. Nurkenov
    T. S. Zhivotova
    A. E. Arinova
    I. S. Tolepbek
    A. N. Zhakupova
    R. E. Bakirova
    L. E. Muravleva
    Pharmaceutical Chemistry Journal, 2016, 50 : 440 - 442
12345