Pyridine-based, microwave-assisted one-pot synthetic protocol for the synthesis of ethyl 3-substituted-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates

被引：1

作者：

Mundra, Sourabh ^{[1
]}

Mahesh, Radhakrishnan ^{[1
]}

机构：

[1] Birla Inst Technol & Sci, Dept Pharm, FD-3, Pilani 333031, Rajasthan, India

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2016年 / 42卷 / 05期

关键词：

5-Carboethoxy-2-thiouracil; Thiourea; Pyrimidine; Microwave irradiation; Synthesis; DIASTEREOSELECTIVE SYNTHESIS; CONDENSATION REACTION; EFFICIENT SYNTHESIS; THERMAL-BEHAVIOR; PTC ALKYLATION; COMPLEXES; DERIVATIVES; ISOOROTATE; PALLADIUM; TRIFLATE;

D O I：

10.1007/s11164-015-2270-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pyridine has been used for one-pot, two-component synthesis of ethyl 3-substituted-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives in moderate to good yields by condensing N-substituted thioureas with diethyl ethoxymalonate under microwave irradiation.

引用

页码：4207 / 4219

页数：13

共 50 条

[1] Pyridine-based, microwave-assisted one-pot synthetic protocol for the synthesis of ethyl 3-substituted-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates
Sourabh Mundra
Radhakrishnan Mahesh
Research on Chemical Intermediates, 2016, 42 : 4207 - 4219
[2] One-pot synthesis of diethyl 4,4′-(1,4-phenylene)bis[6-(halomethyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates] and their bispyrrolocyclization
Iryna O. Lebedyeva
Mykhaylo V. Povstyanoy
Vyacheslav M. Povstyanoy
Oleksandr G. Panasyuk
Evgen S. Guban’
Aleksey B. Ryabitskii
Monatshefte für Chemie - Chemical Monthly, 2010, 141 : 997 - 1000
[3] One-pot synthesis of diethyl 4,4'-(1,4-phenylene)bis[6-(halomethyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates] and their bispyrrolocyclization
Lebedyeva, Iryna O.
Povstyanoy, Mykhaylo V.
Povstyanoy, Vyacheslav M.
Panasyuk, Oleksandr G.
Guban, Evgen S.
Ryabitskii, Aleksey B.
MONATSHEFTE FUR CHEMIE, 2010, 141 (09): : 997 - 1000
[4] Insights into conformational and packing features in a series of aryl substituted ethyl-6-methyl-4-phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates
Nayak, Susanta K.
Venugopala, K. N.
Chopra, Deepak
Row, T. N. Guru
CRYSTENGCOMM, 2011, 13 (02) : 591 - 605
[5] Microwave-assisted one-pot synthesis of 1,2,3,4-tetrahydrocarbazoles
Chen, J
Hu, YZ
SYNTHETIC COMMUNICATIONS, 2006, 36 (11) : 1485 - 1494
[6] Effect of substitution on molecular conformation and packing features in a series of aryl substituted ethyl-6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates
Nayak, Susanta K.
Venugopala, K. N.
Chopra, Deepak
Vasu
Row, T. N. Guru
CRYSTENGCOMM, 2010, 12 (04) : 1205 - 1216
[7] Design and synthesis of 4-[(substituted aminohydroxypropyloxy)phenyl]-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates as vasodilators/beta-adrenoceptor antagonists
Gupta, R
Sudan, S
Kachroo, PL
Jain, SM
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1996, 35 (09): : 985 - 987
[8] One-pot Biginelli synthesis of novel series of 2-oxo/thioxo/imino-1,2,3,4-tetrahydropyrimidine based on 4-hydroxy-2-pyridone
Kamali, Mahmood
Mohammadzadeh, Saeedeh
CHEMICAL PAPERS, 2023, 77 (09) : 4943 - 4952
[9] One-pot Biginelli synthesis of novel series of 2-oxo/thioxo/imino-1,2,3,4-tetrahydropyrimidine based on 4-hydroxy-2-pyridone
Mahmood Kamali
Saeedeh Mohammadzadeh
Chemical Papers, 2023, 77 : 4943 - 4952
[10] ONE-POT SYNTHESIS OF 4-SUBSTITUTED 2-THIOXO-5-OXO-1,3,6-THIADIAZACYCLOOCTANE
BAO, R
HUANG, WQ
ZHEN, Y
HE, BL
SYNTHETIC COMMUNICATIONS, 1990, 20 (17) : 2675 - 2682

← 1 2 3 4 5 →