Nhatrangins A and B, Aplysiatoxin-Related Metabolites from the Marine Cyanobacterium Lyngbya majuscula from Vietnam

被引：50

作者：

Chlipala, George E. ^{[1
]}

Tri, Pham Huu

Hung, Nguyen Van

Krunic, Aleksej ^{[1
]}

Shim, Sang Hee ^{[1
]}

Soejarto, D. Doel ^{[1
]}

Orjala, Jimmy ^{[1
]}

机构：

[1] Univ Illinois, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 04期

关键词：

COUPLING-CONSTANTS; NMR EXPERIMENTS; DEBROMOAPLYSIATOXIN;

D O I：

10.1021/np100002q

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two polyketide metabolites, nhatrangins A (1) and B (2), were isolated from a Vietnamese collection of Lyngbya majuscula. These compounds are related to the aplysiatoxin series of metabolites, which have also been isolated from this species of marine cyanobacterium. The use of 900 MHz cryoprobe NMR allowed the elucidation of the 2D structure of 1 from approximately 0.3 mg of compound. LC-MS analysis was utilized to direct the isolation of additional material as well as the isolation of 2. Conformational analysis was completed using J-based coupling constant analysis and selective NOE experiments.

引用

页码：784 / 787

页数：4

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