Antibody-mediated neutralization of SARS-CoV-2

被引：84
|
作者：
Gruell, Henning [1 ,2 ]
Vanshylla, Kanika [1 ,2 ]
Weber, Timm [1 ,2 ]
Barnes, Christopher O. [3 ,4 ]
Kreer, Christoph [1 ,2 ]
Klein, Florian [1 ,2 ,5 ,6 ]
机构：
[1] Univ Cologne, Fac Med, Inst Virol, Lab Expt Immunol, D-50931 Cologne, Germany
[2] Univ Cologne, Univ Hosp Cologne, D-50931 Cologne, Germany
[3] Stanford Univ, Dept Biol, Stanford, CA 94305 USA
[4] Chan Zuckerberg Biohub, San Francisco, CA 94158 USA
[5] German Ctr Infect Res DZIF, Partner Site Bonn Cologne, D-50931 Cologne, Germany
[6] Univ Cologne, Ctr Mol Med Cologne CMMC, D-50931 Cologne, Germany
来源：
IMMUNITY | 2022年 / 55卷 / 06期
关键词：
MESSENGER-RNA VACCINATION; RECEPTOR-BINDING DOMAIN; B-CELL MEMORY; HUMORAL IMMUNITY; SPIKE PROTEIN; COVID-19; INFECTION; POTENT; MATURATION; PROTECTION;
D O I：
10.1016/j.immuni.2022.05.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Neutralizing antibodies can block infection, clear pathogens, and are essential to provide long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies have been comprehensively investigated and critical information on their development, function, and potential use to prevent and treat COVID-19 have been revealed. With the emergence of SARS-CoV-2 immune escape variants, humoral immunity is being challenged, and a detailed understanding of neutralizing antibodies is essential to guide vaccine design strategies as well as antibody-mediated therapies. In this review, we summarize some of the key findings on SARS-CoV-2 neutralizing antibodies, with a focus on their clinical application.
引用
收藏
页码：925 / 944
页数：20
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