Antibody-mediated neutralization of SARS-CoV-2

被引：84

作者：

Gruell, Henning ^{[1
,2
]}

Vanshylla, Kanika ^{[1
,2
]}

Weber, Timm ^{[1
,2
]}

Barnes, Christopher O. ^{[3
,4
]}

Kreer, Christoph ^{[1
,2
]}

Klein, Florian ^{[1
,2
,5
,6
]}

机构：

[1] Univ Cologne, Fac Med, Inst Virol, Lab Expt Immunol, D-50931 Cologne, Germany

[2] Univ Cologne, Univ Hosp Cologne, D-50931 Cologne, Germany

[3] Stanford Univ, Dept Biol, Stanford, CA 94305 USA

[4] Chan Zuckerberg Biohub, San Francisco, CA 94158 USA

[5] German Ctr Infect Res DZIF, Partner Site Bonn Cologne, D-50931 Cologne, Germany

[6] Univ Cologne, Ctr Mol Med Cologne CMMC, D-50931 Cologne, Germany

来源：

IMMUNITY | 2022年 / 55卷 / 06期

关键词：

MESSENGER-RNA VACCINATION; RECEPTOR-BINDING DOMAIN; B-CELL MEMORY; HUMORAL IMMUNITY; SPIKE PROTEIN; COVID-19; INFECTION; POTENT; MATURATION; PROTECTION;

D O I：

10.1016/j.immuni.2022.05.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neutralizing antibodies can block infection, clear pathogens, and are essential to provide long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies have been comprehensively investigated and critical information on their development, function, and potential use to prevent and treat COVID-19 have been revealed. With the emergence of SARS-CoV-2 immune escape variants, humoral immunity is being challenged, and a detailed understanding of neutralizing antibodies is essential to guide vaccine design strategies as well as antibody-mediated therapies. In this review, we summarize some of the key findings on SARS-CoV-2 neutralizing antibodies, with a focus on their clinical application.

引用

下载

页码：925 / 944

页数：20

共 50 条

[1] Structural insights into antibody-mediated neutralization of SARS-CoV-2
Barnes, Christopher
Scheid, Johannes F.
Eraslan, Basak
Hudak, Andrew
Muecksch, Frauke
Weisblum, Yiska
Bjorkman, Pamela J.
Xavier, Ramnik J.
GLYCOBIOLOGY, 2021, 31 (12) : 1696 - 1697
[2] SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization
Hoffmann, Markus
Zhang, Lu
Krueger, Nadine
Graichen, Luise
Kleine-Weber, Hannah
Hofmann-Winkler, Heike
Kempf, Amy
Nessler, Stefan
Riggert, Joachim
Winkler, Martin Sebastian
Schulz, Sebastian
Jaeck, Hans-Martin
Poehlmann, Stefan
CELL REPORTS, 2021, 35 (03):
[3] Monoclonal antibody-mediated neutralization of SARS-CoV-2 in an IRF9-deficient child
Levy, Romain
Zhang, Peng
Bastard, Paul
Dorgham, Karim
Melki, Isabelle
Hadchouel, Alice
Hartoularos, George C.
Neven, Benedicte
Castelle, Martin
Roy, Charlotte
Toin, Tom
Berteloot, Laureline
Bizien, Lucy
Abid, Hanene
Burgard, Marianne
Houhou-Fidouh, Nadhira
Rozenberg, Flore
Jouanguy, Emmanuelle
Ye, Chun Jimmie
Gorochov, Guy
Zhang, Qian
Casanova, Jean-Laurent
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (45)
[4] Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein
Wrobel, Antoni G.
Benton, Donald J.
Hussain, Saira
Harvey, Ruth
Martin, Stephen R.
Roustan, Chloe
Rosenthal, Peter B.
Skehel, John J.
Gamblin, Steven J.
NATURE COMMUNICATIONS, 2020, 11 (01)
[5] Antibody-mediated SARS-CoV-2 entry in cultured cells
Kibria, Md Golam
Lavine, Christy L.
Tang, Weichun
Wang, Shaowei
Gao, Hailong
Shi, Wei
Zhu, Haisun
Voyer, Jewel
Rits-Volloch, Sophia
Keerti
Bi, Caihong
Peng, Hanqin
Wesemann, Duane R.
Lu, Jianming
Xie, Hang
Seaman, Michael S.
Chen, Bing
EMBO REPORTS, 2023, 24 (12)
[6] Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein
Antoni G. Wrobel
Donald J. Benton
Saira Hussain
Ruth Harvey
Stephen R. Martin
Chloë Roustan
Peter B. Rosenthal
John J. Skehel
Steven J. Gamblin
Nature Communications, 11
[7] Dissecting antibody-mediated protection against SARS-CoV-2
Tomer Zohar
Galit Alter
Nature Reviews Immunology, 2020, 20 : 392 - 394
[8] Dissecting antibody-mediated protection against SARS-CoV-2
Zohar, Tomer
Alter, Galit
NATURE REVIEWS IMMUNOLOGY, 2020, 20 (07) : 392 - 394
[9] The Evolutionary Arms Race Between Antibody-Mediated Immunity And SARS-Cov-2
Bates, Timothy
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2022, 78 : A320 - A320
[10] Lack of antibody-mediated cross-protection between SARS-CoV-2 and SARS-CoV infections
Yang, Ren
Lan, Jiaming
Huang, Baoying
Ruhan, A.
Lu, Mingqing
Wang, Wen
Wang, Wenling
Li, Wenhui
Deng, Yao
Wong, Gary
Tan, Wenjie
EBIOMEDICINE, 2020, 58

← 1 2 3 4 5 →