The Relationship between Cognitive Functions and Psychopathological Symptoms in First Episode Psychosis and Chronic Schizophrenia

被引:10
|
作者
Rek-Owodzin, Katarzyna [1 ]
Tyburski, Ernest [1 ]
Plichta, Piotr [1 ]
Waszczuk, Katarzyna [2 ]
Bielecki, Maksymilian [1 ]
Wietrzynski, Krzysztof [1 ]
Podwalski, Piotr [2 ]
Rudkowski, Krzysztof [2 ]
Michalczyk, Anna [2 ]
Grazlewski, Tomasz [2 ]
Sagan, Leszek [3 ]
Kucharska-Mazur, Jolanta [2 ]
Samochowiec, Jerzy [2 ]
Mak, Monika [1 ]
机构
[1] Pomeranian Med Univ, Dept Hlth Psychol, PL-71457 Szczecin, Poland
[2] Pomeranian Med Univ, Dept Psychiat, PL-71457 Szczecin, Poland
[3] Pomeranian Med Univ, Dept Neurosurg, PL-71252 Szczecin, Poland
关键词
first-episode psychosis; chronic schizophrenia; cognitive functions; psychopathology; MATRICS Consensus Cognitive Battery; MCCB; PANSS; 1ST-EPISODE PSYCHOSIS; BATTERY; NEUROCOGNITION; IMPAIRMENT; DEFICITS; DISORGANIZATION; METAANALYSIS; RISK;
D O I
10.3390/jcm11092619
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Impairments in cognitive functions are one of the main features of schizophrenia. A variety of factors can influence the extent of cognitive deficits. In our study, we examined the severity of cognitive deficits at different stages of the disease and the relationship between psychopathological symptoms and cognitive functions. We recruited 32 patients with first-episode psychosis (FEP), 70 with chronic schizophrenia (CS), and 39 healthy controls (HC). Psychopathological symptoms were evaluated with the Positive and Negative Syndrome Scale (PANSS) and cognitive functions were measured with the MATRICS Cognitive Consensus Battery (MCCB). Cognitive deficits were present in both FEP and CS participants. CS individuals had lower overall scores and poorer working memory; however, clinical variables appeared to play a significant role in these scores. In FEP, disorganization correlated negatively with verbal and visual learning and memory, social cognition, and overall score; negative symptoms negatively correlated with social cognition. In CS participants, disorganization correlated negatively with speed of processing, reasoning, problem solving, and overall score; negative symptoms were negatively correlated with speed of processing, visual learning, memory, and overall score; positive symptoms were negatively correlated with reasoning and problem solving. Our findings indicate that psychopathological symptoms have a significant impact on cognitive functions in FEP and CS patients.
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页数:14
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