Epidermal Barrier Protects against Age-Associated Systemic Inflammation

被引：15
|
作者：
Velarde, Michael C. [1 ]
机构：
[1] Univ Philippines Diliman, Inst Biol, Quezon City, Philippines
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2017年 / 137卷 / 06期
关键词：
CYTOKINE PRODUCTION; EXPRESSION; SKIN;
D O I：
10.1016/j.jid.2017.02.964
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Skin provides barrier protection for the body, but aging disrupts epidermal barrier function. Hu et al. show that disruption of the epidermal barrier increases serum cytokine levels partly because of increased cytokine production by the skin. They then show that restoring epidermal barrier function in aged mice reduces circulating levels of proinflammatory cytokines.
引用
收藏
页码：1206 / 1208
页数：4
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