Alemtuzumab: effective monotherapy for simultaneous B-cell chronic lymphocytic leukaemia and Sezary syndrome

被引:12
|
作者
Gibbs, SDJ
Herbert, KE
McCormack, C
Seymour, JF
Prince, HM
机构
[1] Peter MacCallum Canc Inst, Dept Haematol, Haematol Serv, Melbourne, Vic 8006, Australia
[2] St Vincents Hosp, Dept Dermatol, Melbourne, Vic, Australia
关键词
alemtuzumab; chronic lymphocytic leukaemia; Sezary syndrome; pancytopenia;
D O I
10.1111/j.1600-0609.2004.00332.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The simultaneous presentation of chronic lymphocytic leukaemia (CLL) and cutaneous T-cell lymphoma (CTCL) is a very rare occurrence where optimal treatment is unknown. We present the case of a 65-yr-old man who was successfully treated with alemtuzumab monotherapy for both disorders, but at a cost of severe infectious morbidity and prolonged pancytopenia.
引用
收藏
页码:447 / 449
页数:3
相关论文
共 50 条
  • [31] Inactivation of the ATM gene in B-cell chronic lymphocytic leukaemia.
    Stankovic, T
    Weber, P
    Stewart, G
    Bedenham, T
    Murray, J
    Fegan, CD
    Byrd, PJ
    Moss, PAH
    Taylor, AMR
    BRITISH JOURNAL OF HAEMATOLOGY, 1999, 105 : 70 - 70
  • [32] B-cell chronic lymphocytic leukaemia in an African lion (Panthera leo)
    Meoli, R.
    Eleni, C.
    Cavicchio, P.
    Tonnicchia, M. C.
    Biancani, B.
    Galosi, L.
    Rossi, G.
    VETERINARNI MEDICINA, 2018, 63 (09) : 433 - 437
  • [33] Unusual primary cutaneous presentation of B-cell chronic lymphocytic leukaemia
    Mavropoulou, S.
    Tatsiou, Z.
    Xanthopoulidis, G.
    Goutzouvelidis, A.
    VIRCHOWS ARCHIV, 2012, 461 : S201 - S201
  • [34] Regulation and function of adhesion molecules in B-cell chronic lymphocytic leukaemia
    Jewell, AP
    Yong, KL
    ACTA HAEMATOLOGICA, 1997, 97 (1-2) : 67 - 72
  • [35] Wnt signalling pathways in chronic lymphocytic leukaemia and B-cell lymphomas
    Janovska, Pavlina
    Bryja, Vitezslav
    BRITISH JOURNAL OF PHARMACOLOGY, 2017, 174 (24) : 4701 - 4715
  • [36] Expression and production of interleukin 4 in B-cell chronic lymphocytic leukaemia
    Mainou-Fowler, T
    Proctor, SJ
    Miller, S
    Dickinson, AM
    LEUKEMIA & LYMPHOMA, 2001, 42 (04) : 689 - 698
  • [37] A systematic overview of chemotherapy effects in B-cell chronic lymphocytic leukaemia
    Kimby, E
    Brandt, L
    Nygren, P
    Glimelius, B
    ACTA ONCOLOGICA, 2001, 40 (2-3) : 224 - 230
  • [38] Richter syndrome first manifesting as cutaneous B-cell lymphoma clonally distinct from primary B-cell chronic lymphocytic leukaemia
    Robak, E
    Góra-Tybor, J
    Kordek, R
    Wawrzyniak, E
    Bartkowiak, J
    Bednarek, A
    Constantinou, M
    Kaluzewski, B
    Robak, T
    BRITISH JOURNAL OF DERMATOLOGY, 2005, 153 (04) : 833 - 837
  • [39] Richter syndrome in B-cell chronic lymphocytic leukemia
    Nakamura, N
    Abe, M
    PATHOLOGY INTERNATIONAL, 2003, 53 (04) : 195 - 203
  • [40] Alemtuzumab is effective in patients with advanced, pretreated B-cell chronic lymphocytic leukemia: A nationwide study of routine use in Austria
    Fiegl, M
    Falkner, A
    Hopfinger, G
    Brugger, S
    Zabernigg, A
    Haslbauer, F
    Andel, J
    Thaler, J
    Fridrik, M
    Bauer, F
    Mian, M
    Tatzreiter, G
    Zoier, N
    Demirtas, D
    Postner, G
    Auberger, J
    Gastl, G
    Greil, R
    BLOOD, 2005, 106 (11) : 833A - 833A