Increased REM sleep after intra-locus coeruleus nucleus microinjection of melanin-concentrating hormone (MCH) in the rat

被引：33

作者：

Monti, Jaime M. ^{[1
]}

Lagos, Patricia ^{[2
]}

Jantos, Hector ^{[1
]}

Torterolo, Pablo ^{[2
]}

机构：

[1] Clin Hosp, Sch Med, Dept Pharmacol & Therapeut, Montevideo 11600, Uruguay

[2] Sch Med, Dept Physiol, Montevideo 11300, Uruguay

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2015年 / 56卷

关键词：

Locus coeruleus; Melanin-concentrating hormone; Noradrenaline; REM sleep; Sleep; DORSAL RAPHE; NEURONS; PROJECTIONS; BEHAVIORS; GENESIS; GABA;

D O I：

10.1016/j.pnpbp.2014.09.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A study was carried out on the effects of unilateral microinjection of melanin-concentrating hormone (MCH) into the right locus coeruleus (LC) on the sleep-wake cycle in rats prepared for chronic sleep recordings. MCH 200 ng significantly augmented rapid-eye-movement sleep (REMS) time during the first, second and third 2-h of recording. Furthermore, MCH 100 ng induced a significant increase of REMS during the first 2-h period after treatment. The increment of the behavioral state was related to a greater number of REMS episodes. It is suggested that MCH deactivation of noradrenergic neurons located in the LC facilitates the occurrence of REMS. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：185 / 188

页数：4

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