A Biomolecular "Ship-in-a-Bottle": Continuous RNA Synthesis Within Hollow Polymer Hydrogel Assemblies

被引：42

作者：

Price, Andrew D. ^{[1
]}

Zelikin, Alexander N. ^{[1
]}

Wark, Kim L. ^{[2
]}

Caruso, Frank ^{[1
]}

机构：

[1] Univ Melbourne, Dept Chem & Biomol Engn, Ctr Nanosci & Nanotechnol, Parkville, Vic 3010, Australia

[2] CSIRO, Div Mol & Hlth Technol, Parkville, Vic 3052, Australia

来源：

ADVANCED MATERIALS | 2010年 / 22卷 / 06期

基金：

澳大利亚研究理事会;

关键词：

CAPSULES; DNA; MICROREACTORS; PERMEABILITY; DELIVERY; FILMS; LIFE;

D O I：

10.1002/adma.200903411

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of micrometer-sized, monodisperse polymer hydrogel capsules that act as both microreactors and drug carriers for de novo synthesized RNA is demonstrated (see figure). These capsules are expected to have broad impact as biophysical tools for the study of encapsulated RNA and as new biocompatible delivery vehicles for the cellular delivery of RNA therapeutics.

引用

页码：720 / +

页数：5