A New Synthetic Route Towards Aliskiren Intermediates

被引：3
|
作者：
Pozgan, Franc [1 ]
Stefane, Bogdan [1 ]
Kidemet, Davor [2 ]
Smodis, Janez [2 ]
Zupet, Rok [2 ]
机构：
[1] Univ Ljubljana, Fac Chem & Chem Technol, Ljubljana 1000, Slovenia
[2] Krka Pharmaceut Co Dd, Novo Mesto 8501, Slovenia
来源：
SYNTHESIS-STUTTGART | 2014年 / 46卷 / 23期
关键词：
aliskiren; Grignard reagents; boronic acid; acyl chloride; coupling; CROSS-COUPLING REACTION; POTENT RENIN INHIBITOR; ACYL CHLORIDES; ARYLBORONIC ACIDS; CONVERGENT SYNTHESIS; CARBOXYLIC ANHYDRIDES; KETONES; LIGANDLESS; REAGENTS; SYSTEM;
D O I：
10.1055/s-0034-1378616
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of aliskiren intermediates was accomplished by attaching the 3,4-dialkoxyphenyl unit to precursor C-8 lactone-carboxylic acid derivatives using organometallic reagents. Totally different reactivities of the lactone-carboxylic acid chloride substrate towards organomagnesium and organoboron reagents were observed.
引用
收藏
页码：3221 / 3228
页数：8
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