Effect of an increased clopidogrel maintenance dose or lansoprazole co-administration on the antiplatelet response to clopidogrel in CYP2C19-genotyped healthy subjects

被引:32
|
作者
Hulot, J. -S. [1 ,2 ,3 ]
Wuerzner, G. [4 ]
Bachelot-Loza, C. [5 ]
Azizi, M. [4 ,6 ]
Blanchard, A. [4 ]
Peyrard, S. [4 ]
Funck-Brentano, C. [1 ,2 ,3 ]
Gaussem, P. [5 ,6 ,7 ]
机构
[1] Hop La Pitie Salpetriere, AP HP, Serv Pharmacol, Unite Pharmacogenet,Ctr Invest Biomed, F-75013 Paris, France
[2] Univ Paris, UPMC, Paris, France
[3] INSERM, UMR S 956, Paris, France
[4] Hop Europeen Georges Pompidou, AP HP, Ctr Invest Clin, INSERM,CIC 9201, Paris, France
[5] INSERM, UMR S 765, Fac Pharm, Paris, France
[6] Univ Paris 05, Paris, France
[7] Hop Europeen Georges Pompidou, AP HP, Serv Hematol Biol, Paris, France
关键词
OF-FUNCTION POLYMORPHISM;
D O I
10.1111/j.1538-7836.2009.03729.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:610 / 613
页数:4
相关论文
共 50 条
  • [41] Impact of CYP2C19*2 loss-of-function polymorphisms on platelet reactivity after loading dose of clopidogrel in healthy Malaysian volunteers
    Sani, Yanti N.
    Lim, Sheau C.
    Lim, Luen H.
    Edwin, Elyana Y.
    Khan, Nurzalina A. K.
    Goh, Teck H.
    Serebruany, Victor L.
    Yuen, Kah H.
    PHARMACOTHERAPY, 2012, 32 (05): : E113 - E114
  • [42] The effect of CYP2C19*17 on platelet response and clinical outcomes in patients taking clopidogrel: a meta-analysis
    Fang, H.
    THERAPEUTIC DRUG MONITORING, 2011, 33 (04) : 479 - 479
  • [43] ASSOCIATION OF GENETIC (CYP2C19, CYP2C9 AND P2Y12 SNPS) AND NON GENETIC FACTORS WITH ANTIPLATELET EFFECT OF CLOPIDOGREL IN ISCHEMIC STROKE PATIENTS
    Gairolla, J.
    Khullar, M.
    Ahluwalia, J.
    Medhi, B.
    Kler, R.
    Modi, M.
    Khurana, D.
    INTERNATIONAL JOURNAL OF STROKE, 2016, 11 (SUPP 3) : 55 - 56
  • [44] Evaluation of CYP2C19, P2Y12, and ABCB1 polymorphisms and phenotypic response to clopidogrel in healthy Indian adults
    Sridharan, Kannan
    Kataria, Rachna
    Tolani, Drishti
    Bendkhale, Shital
    Gogtay, Nithya J.
    Thatte, Urmila M.
    INDIAN JOURNAL OF PHARMACOLOGY, 2016, 48 (04) : 350 - 354
  • [45] Proton Pumps Inhibitors and Clopidogrel Interaction: Effect of Rabeprazole on the Anti-Platelet Function of Clopidogrel in Relation to CYP2C19 Genotype Status. A Prospective, Randomized, 3-way Crossover PK/PD Study in Healthy Subjects
    Coudsy, Bogdana
    Funck-Brentano, Christian
    Blanchard, Anne
    Frank, Michael
    Szymezak, Jean
    Remones, Veronique
    Verhaeghe, Tom
    Solanki, Bhavna
    Molimard, Mathieu
    Ducint, Dominique
    Azizi, Michel
    Gaussem, Pascale
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2011, 106 : S13 - S13
  • [46] Impact of polymorphic expression of cytochrome P450 2C19 and CYP 2C9 on antiplatelet effect of a 600-mg loading dose of clopidogrel in a large cohort of patients undergoing PCI
    Trenk, D.
    Hochholzer, W.
    Fromm, M. F.
    Zolk, O.
    Pahl, A.
    Neumann, F. -J.
    EUROPEAN HEART JOURNAL, 2008, 29 : 759 - 759
  • [47] Changes in CYP2C19 enzyme activity evaluated by the [13C]-pantoprazole breath test after co-administration of clopidogrel and proton pump inhibitors following percutaneous coronary intervention and correlation to platelet reactivity
    Harvey, Adrien
    Modak, Anil
    Dery, Ugo
    Roy, Melanie
    Rinfret, Stephane
    Bertrand, Olivier F.
    Larose, Eric
    Rodes-Cabau, Josep
    Barbeau, Gerald
    Gleeton, Onil
    Can Manh Nguyen
    Proulx, Guy
    Noel, Bernard
    Roy, Louis
    Paradis, Jean-Michel
    De Larochelliere, Robert
    Dery, Jean-Pierre
    JOURNAL OF BREATH RESEARCH, 2016, 10 (01)
  • [48] A randomized controlled trial of adjunctive Bunchang Naoxintong Capsule (步长脑心通胶囊) versus maintenance dose clopidogrel in patients with CYP2C19*2 polymorphism
    Hui Chen
    Xiao-ying Wu
    Hong-xia Wu
    Huan Wang
    Chinese Journal of Integrative Medicine, 2014, 20 : 894 - 902
  • [49] A Randomized Controlled Trial of Adjunctive Bunchang Naoxintong Capsule (步长脑心通胶囊) Versus Maintenance Dose Clopidogrel in Patients with CYP2C19*2 Polymorphism
    陈慧
    吴小盈
    吴红霞
    王欢
    Chinese Journal of Integrative Medicine, 2014, (12) : 894 - 902
  • [50] A Randomized Controlled Trial of Adjunctive Bunchang Naoxintong Capsule (步长脑心通胶囊) Versus Maintenance Dose Clopidogrel in Patients with CYP2C19*2 Polymorphism
    陈慧
    吴小盈
    吴红霞
    王欢
    Chinese Journal of Integrative Medicine, 2014, 20 (12) : 894 - 902