Chalcomycin: Single-crystal X-ray crystallographic analysis; Biosynthetic and stereochemical correlations with other polyoxo macrolide antibiotics.

被引：15
|
作者：
Woo, PWK
Rubin, JR
机构：
[1] Parke-Davis Pharmaceutical Res. D., Ann Arbor, MI 48105
来源：
TETRAHEDRON | 1996年 / 52卷 / 11期
关键词：
D O I：
10.1016/S0040-4020(96)00052-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The stereochemistry of chalcomycin (1), a neutral 16-membered macrolide antibiotic, was established by X-ray crystallography. A correlation model for 16-membered macrolides (2), together with its biochemical rationale, is presented and applied to the configurational assignment of seven other analogous neutral macrolides (aldgamycins F, G, CP-61,884 complex, neutramycin, and swalpamycin). The chalcomycin molecule appears to be conformationally restrained in a rigid manner.
引用
收藏
页码：3857 / 3872
页数：16
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