Immunohistochemical Distribituon of COX-1, COX-2, and TGFβ-1 in the Duodenum of Rats Treated with Capsaicin

被引：0
|
作者：
Bakir, Buket [1 ]
Elis Yildiz, Sevda [2 ]
Karadag Sari, Ebru [3 ]
Asker, Hasan [3 ]
Nazli, Mumtaz [4 ]
机构：
[1] Namik Kemal Univ, Dept Histol Embryol, Fac Vet Med, TR-59000 Tekirdag, Turkey
[2] Kafkas Univ, Sch Hlth Sci, TR-36040 Kars, Turkey
[3] Kafkas Univ, Fac Vet Med, Dept Histol Embryol, TR-36040 Kars, Turkey
[4] Mugla Sitki Kocman Univ, Dept Histol Embryol, Fac Med, TR-48000 Mugla, Turkey
来源：
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI | 2016年 / 22卷 / 03期
关键词：
Capsaicin; Cyclooxygenase; Duodenum; Transforming growth factor beta-1; GROWTH-FACTOR-ALPHA; EPITHELIAL-CELLS; FACTOR-BETA; CYCLOOXYGENASE; GENE-EXPRESSION; PAIN MANAGEMENT; SMALL-INTESTINE; MESSENGER-RNA; RECEPTOR; MICE;
D O I：
10.9775/kvfd.2015.14559
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The purpose of this study was to investigate the effects of capsaicin on the duodenal distribution of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and Transforming growth factor beta-1 (TGF beta-1) in rats. Rats were divided into two groups (n = 10 in each group). Experimental group treated with capsaicin (1 mg/kg, subcutaneously) was injected in 10% ethanol, 1% Tween and 80% distilled water everyday for a period of one week and in not injected control group. Localisations of COX-1, COX-2 and TGF beta-1 were observed in villus and crypt ephitelial cells, and smooth muscle cells. In conclusion, in this study, capsaicin administration was found to increase the release of COX-1 and COX-2, and TGF beta-1.
引用
收藏
页码：333 / 338
页数：6
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