Transient depletion of pre-existing antibodies for efficient AAV gene delivery

被引：0
|
作者：
Fu, Haiyan [1 ]
Samowitz, Preston [1 ]
Forsberg, John [1 ]
Feng, Richard [1 ]
Nicely, Nathan [1 ]
Bobo, Tierra [1 ]
机构：
[1] Univ North Carolina Chapel Hill, Chapel Hill, NC USA
来源：
MOLECULAR GENETICS AND METABOLISM | 2022年 / 135卷 / 02期
关键词：
D O I：
10.1016/j.ymgme.2021.11.103
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
88
引用
收藏
页码：S44 / S44
页数：1
相关论文
共 50 条
  • [1] Transient Depletion of Pre-Existing Antibodies for Efficient AAV Gene Delivery Treating MPS IIIA in Mice
    Fu, Haiyan
    Samowitz, Preston
    Robinson, Michael
    Forsberg, John
    Feng, Richard
    Nicely, Nathan
    Bobo, Tierra
    MOLECULAR THERAPY, 2022, 30 (04) : 130 - 130
  • [2] A Novel Approach for Rapid and Transient Depletion of Pre-Existing Neutralizing Antibodies Against AAV Vectors
    Elmore, Zachary
    Oh, Daniel
    Simon, Katherine
    Fanous, Marco
    Asokan, Aravind
    MOLECULAR THERAPY, 2020, 28 (04) : 398 - 398
  • [3] Delivery of AAV-hAADC to rats with pre-existing immunity to AAV
    Sanftner, L
    Suzuki, B
    Doroudchi, M
    Feng, L
    McClelland, A
    Forsayeth, J
    Cunningham, J
    MOLECULAR THERAPY, 2003, 7 (05) : S90 - S90
  • [4] Effective Depletion of Pre-Existing Anti-AAV Antibodies Requires Broad Immune Targeting
    Fu, Haiyan
    Meadows, Aaron S.
    Velazquez, Victoria
    Camboni, Marybeth
    Pineda, Ricardo
    Duncan, F. Jason
    Walker, Christopher M.
    McCarty, Douglas M.
    MOLECULAR THERAPY, 2016, 24 : S276 - S276
  • [5] Effective Depletion of Pre-existing Anti-AAV Antibodies Requires Broad Immune Targeting
    Velazquez, Victoria M.
    Meadows, Aaron S.
    Pineda, Ricardo J.
    Camboni, Marybeth
    McCarty, Douglas M.
    Fu, Haiyan
    MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2017, 4 : 159 - 168
  • [6] Impacts of Pre-Existing Antibodies on Transduction Efficiency of Systemic AAV9 Gene Delivery: Potential for Broader Patient Eligibility for AAV Gene Therapy
    Meadows, Aaron S.
    Pineda, Ricardo
    Fu, Haiyan
    MOLECULAR THERAPY, 2018, 26 (05) : 102 - 103
  • [7] Influence of Pre-Existing Neutralizing Antibodies on Gene Expression Following Intramuscular Administration of AAV Vectors
    Greig, Jenny A.
    McMenamin, Deirdre
    Wilson, James M.
    MOLECULAR THERAPY, 2011, 19 (07) : 1364 - 1365
  • [8] Pre-existing Anti-Adeno-Associated Virus Antibodies as a Challenge in AAV Gene Therapy
    Jeune, Vedell Louis
    Joergensen, Jakob A.
    Hajjar, Roger J.
    Weber, Thomas
    HUMAN GENE THERAPY METHODS, 2013, 24 (02) : 59 - U89
  • [9] Strategy to detect pre-existing immunity to AAV gene therapy
    Falese, L.
    Sandza, K.
    Yates, B.
    Triffault, S.
    Gangar, S.
    Long, B.
    Tsuruda, L.
    Carter, B.
    Vettermann, C.
    Zoog, S. J.
    Fong, S.
    GENE THERAPY, 2017, 24 (12) : 768 - 778
  • [10] Strategy to detect pre-existing immunity to AAV gene therapy
    L Falese
    K Sandza
    B Yates
    S Triffault
    S Gangar
    B Long
    L Tsuruda
    B Carter
    C Vettermann
    S J Zoog
    S Fong
    Gene Therapy, 2017, 24 : 768 - 778
12345