Transient Depletion of Pre-Existing Antibodies for Efficient AAV Gene Delivery Treating MPS IIIA in Mice

被引:0
|
作者
Fu, Haiyan [1 ]
Samowitz, Preston [1 ]
Robinson, Michael [1 ]
Forsberg, John [1 ]
Feng, Richard [1 ]
Nicely, Nathan [1 ]
Bobo, Tierra [1 ]
机构
[1] Univ N Carolina, Gene Therapy Ctr, Chapel Hill, NC USA
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
270
引用
收藏
页码:130 / 130
页数:1
相关论文
共 50 条
  • [1] Transient depletion of pre-existing antibodies for efficient AAV gene delivery
    Fu, Haiyan
    Samowitz, Preston
    Forsberg, John
    Feng, Richard
    Nicely, Nathan
    Bobo, Tierra
    MOLECULAR GENETICS AND METABOLISM, 2022, 135 (02) : S44 - S44
  • [2] A Novel Approach for Rapid and Transient Depletion of Pre-Existing Neutralizing Antibodies Against AAV Vectors
    Elmore, Zachary
    Oh, Daniel
    Simon, Katherine
    Fanous, Marco
    Asokan, Aravind
    MOLECULAR THERAPY, 2020, 28 (04) : 398 - 398
  • [3] Delivery of AAV-hAADC to rats with pre-existing immunity to AAV
    Sanftner, L
    Suzuki, B
    Doroudchi, M
    Feng, L
    McClelland, A
    Forsayeth, J
    Cunningham, J
    MOLECULAR THERAPY, 2003, 7 (05) : S90 - S90
  • [4] Effective Depletion of Pre-Existing Anti-AAV Antibodies Requires Broad Immune Targeting
    Fu, Haiyan
    Meadows, Aaron S.
    Velazquez, Victoria
    Camboni, Marybeth
    Pineda, Ricardo
    Duncan, F. Jason
    Walker, Christopher M.
    McCarty, Douglas M.
    MOLECULAR THERAPY, 2016, 24 : S276 - S276
  • [5] Effective Depletion of Pre-existing Anti-AAV Antibodies Requires Broad Immune Targeting
    Velazquez, Victoria M.
    Meadows, Aaron S.
    Pineda, Ricardo J.
    Camboni, Marybeth
    McCarty, Douglas M.
    Fu, Haiyan
    MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2017, 4 : 159 - 168
  • [6] Impacts of Pre-Existing Antibodies on Transduction Efficiency of Systemic AAV9 Gene Delivery: Potential for Broader Patient Eligibility for AAV Gene Therapy
    Meadows, Aaron S.
    Pineda, Ricardo
    Fu, Haiyan
    MOLECULAR THERAPY, 2018, 26 (05) : 102 - 103
  • [7] Gene Therapy for MPS VI Is Effective in Cats without Pre-Existing Immunity to AAV8
    Ferla, Rita
    O'Malley, Thomas
    Calcedo, Roberto
    O'Donnell, Patricia
    Wang, Ping
    Cotugno, Gabriella
    Claudiani, Pamela
    Wilson, James M.
    Haskins, Mark
    Auricchio, Alberto
    MOLECULAR THERAPY, 2013, 21 : S138 - S139
  • [8] Influence of Pre-Existing Neutralizing Antibodies on Gene Expression Following Intramuscular Administration of AAV Vectors
    Greig, Jenny A.
    McMenamin, Deirdre
    Wilson, James M.
    MOLECULAR THERAPY, 2011, 19 (07) : 1364 - 1365
  • [9] Pre-existing Anti-Adeno-Associated Virus Antibodies as a Challenge in AAV Gene Therapy
    Jeune, Vedell Louis
    Joergensen, Jakob A.
    Hajjar, Roger J.
    Weber, Thomas
    HUMAN GENE THERAPY METHODS, 2013, 24 (02) : 59 - U89
  • [10] Strategy to detect pre-existing immunity to AAV gene therapy
    Falese, L.
    Sandza, K.
    Yates, B.
    Triffault, S.
    Gangar, S.
    Long, B.
    Tsuruda, L.
    Carter, B.
    Vettermann, C.
    Zoog, S. J.
    Fong, S.
    GENE THERAPY, 2017, 24 (12) : 768 - 778