Acetate Fuels the Cancer Engine

被引：87
|
作者：
Lyssiotis, Costas A. [1 ]
Cantley, Lewis C. [1 ]
机构：
[1] Weill Cornell Med Coll, Meyer Canc Ctr, Dept Med, New York, NY 10065 USA
来源：
CELL | 2014年 / 159卷 / 07期
关键词：
METABOLISM;
D O I：
10.1016/j.cell.2014.12.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer cells have distinctive nutrient demands to fuel growth and proliferation, including the disproportionate use of glucose, glutamine, and fatty acids. Comerford et al. and Mashimo et al. now demonstrate that several types of cancer are avid consumers of acetate, which facilitates macromolecular biosynthesis and histone modification.
引用
收藏
页码：1492 / 1494
页数：4
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