Copper-Catalyzed Synthesis of Substituted 2,4-Diamino-1,3,5-triazines from 1,1-Dibromoalkenes and Biguanides

被引：31

作者：

Zhang, Chen ^{[1
]}

Ban, Meng-Tao ^{[1
]}

Zhu, Kai ^{[2
]}

Zhang, Li-Yu ^{[3
]}

Luo, Zhen-Yu ^{[1
]}

Guo, Shun-Na ^{[1
]}

Cui, Dong-Mei ^{[2
]}

Zhang, Yu ^{[3
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

[2] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China

[3] Jiamusi Univ, Sch Pharmaceut Sci, Jiamusi 154007, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 15期

关键词：

MICROWAVE-ASSISTED SYNTHESIS; REGIOSELECTIVE SYNTHESIS; EFFICIENT SYNTHESIS; TRIAZINE DENDRIMERS; ARYL ALDEHYDES; S-TRIAZINES; PALLADIUM; 1,1-DIBROMO-1-ALKENES; DERIVATIVES; 1,3,5-TRIAZINES;

D O I：

10.1021/acs.orglett.7b01608

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient copper-catalyzed synthesis of substituted 2,4-diamino-1,3,5-triazines from 1,1-dibromoalkenes and biguanides under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated alkyl-, heterocyclic-, or aryl-substituted 1,1-dibromoalkenes containing functionalities such as nitriles, ethers, and halogens. Monosubstituted to tetrasubstituted biguanidines also afforded the desired products.

引用

页码：3947 / 3949

页数：3

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