Establishment of A New HBV Cell Culture Model by Covalently Closed Circular DNA Direct Transfect

被引：1
|
作者：
Zhao, Zhonghua [1 ]
Tang, Yuwei [1 ]
Wei, Qinglv [1 ]
Zhang, Huatang [1 ]
机构：
[1] Chongqing Acad Sci & Technol, Chongqing, Peoples R China
来源：
2020 ASIA CONFERENCE ON GEOLOGICAL RESEARCH AND ENVIRONMENTAL TECHNOLOGY | 2021年 / 632卷
基金：
中国国家自然科学基金;
关键词：
HEPATITIS-B-VIRUS; INFECTION;
D O I：
10.1088/1755-1315/632/3/032023
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Hepatitis B virus (HBV) infection is a public health problem in China and worldwide. Covalently closed circular DNA (cccDNA) is the template for HBV replication and exists stably in hepatocytes, which is the main factor for persistent HBV infection and the key target for the cure of HBV infection. The establishment of a suitable cell model is helpful to research the HBV pathogenesis and antiviral drug screening. We have established a new cell culture model of HBV infection by direct transfect of cccDNA, which provides a practical model for further research of HBV virology and antiviral drug development.
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页数：7
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