Holographic optical coherence imaging of tumor spheroids

被引:60
|
作者
Yu, P
Mustata, M
Turek, JJ
French, PMW
Melloch, MR
Nolte, DD
机构
[1] Purdue Univ, Dept Phys, W Lafayette, IN 47907 USA
[2] Purdue Univ, Sch Vet Med, Dept Basic Med Sci, W Lafayette, IN 47907 USA
[3] Univ London Imperial Coll Sci Technol & Med, Dept Phys, London SW7 2BZ, England
[4] Purdue Univ, Sch Elect & Comp Engn, W Lafayette, IN 47907 USA
关键词
D O I
10.1063/1.1594830
中图分类号
O59 [应用物理学];
学科分类号
摘要
We present depth-resolved coherence-domain images of living tissue using a dynamic holographic semiconductor film. An AlGaAs photorefractive quantum-well device is used in an adaptive interferometer that records coherent backscattered (image-bearing) light from inside rat osteogenic sarcoma tumor spheroids up to 1 mm in diameter in vitro. The data consist of sequential holographic image frames at successive depths through the tumor represented as a visual video "fly-through." The images from the tumor spheroids reveal heterogeneous structures presumably caused by necrosis and microcalcifications characteristic of human tumors in their early avascular growth. (C) 2003 American Institute of Physics.
引用
收藏
页码:575 / 577
页数:3
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