A Powerful Method for the Direct Arylation of Furans at a Sterically Congested C-H Bond

被引：6

作者：

Nishikata, Takashi ^{[1
]}

Yamane, Yu ^{[1
]}

Yamaguchi, Yousui ^{[1
]}

Ishikawa, Shingo ^{[1
]}

机构：

[1] Yamaguchi Univ, Grad Sch Sci & Engn, 2-16-1 Tokiwadai, Ube, Yamaguchi 7558611, Japan

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 5卷 / 04期

关键词：

arylation; C-H activation; cross-coupling; furans; palladium; PROTON-ABSTRACTION MECHANISM; TETRASUBSTITUTED FURANS; CATALYZED BORYLATION; SUBSTITUTED FURANS; COUPLING REACTIONS; RECENT PROGRESS; C-4; ARYLATION; PALLADIUM; FUNCTIONALIZATION; HETEROARENES;

D O I：

10.1002/ajoc.201600057

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The direct arylation of furans at a sterically congested C-H bond are accomplished. Although there are many methods for catalytic C-H arylation, direct C-H arylation at bulky reaction sites is one of the most problematic issues in this area. In this study, we found that a PdCl2-1,2-bis(dicyclohexylphosphino)ethane (dcype) or PCy3 and silver salt system enables arylations at a sterically congested C-H bonds to produce highly congested and very congested triarylfurans.

引用

页码：466 / 469

页数：4

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