Inherited susceptibility to breast and ovarian cancer

被引：4

作者：

Diamond, TM ^{[1
]}

Sutphen, R ^{[1
]}

Tabano, M ^{[1
]}

Fiorica, J ^{[1
]}

机构：

[1] Univ S Florida, Dept Pediat, Tampa, FL 33620 USA

来源：

CURRENT OPINION IN OBSTETRICS & GYNECOLOGY | 1998年 / 10卷 / 01期

关键词：

D O I：

10.1097/00001703-199802000-00002

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Approximately 5-10% of breast and ovarian cancer cases are due to an inherited susceptibility. The majority of inherited breast and ovarian cancer susceptibility is due to mutations in the BRCA1 and BRCA2 genes; however, other genes responsible for inherited susceptibility to these diseases are yet to be identified. A small proportion of inherited breast and ovarian cancers are due to other genetic cancer susceptibility syndromes including Li-Fraumeni syndrome, Cowden disease and hereditary nonpolyposis colorectal cancer. It is recommended that individuals at risk for inherited susceptibility to breast and/or ovarian cancer who are requesting DNA testing be provided with pre-test genetic counseling and education and post-test counseling and follow-up to ensure that all aspects of genetic testing have been disclosed and that the patient has truly given informed consent. 1040-872X (C) 1998 Rapid Science Publishers.

引用

页码：3 / 8

页数：6

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