Diffusion-Influenced Transport of Ions across a Transmembrane Channel with an Internal Binding Site

被引：21

作者：

Zhou, Huan-Xiang ^{[1
,2
]}

机构：

[1] Florida State Univ, Dept Phys, Tallahassee, FL 32306 USA

[2] Florida State Univ, Inst Mol Biophys, Tallahassee, FL 32306 USA

来源：

JOURNAL OF PHYSICAL CHEMISTRY LETTERS | 2010年 / 1卷 / 13期

基金：

美国国家卫生研究院;

关键词：

M2 PROTON CHANNEL; A VIRUS; MECHANISM; PROTEIN; CONDUCTANCE; MODEL; GATE;

D O I：

10.1021/jz100683t

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We develop a microscopic theory for ion transport across a transmembrane channel with an internal binding site. The ion flux is determined by the rate constants for binding to the internal site from the two sides of the membrane and the corresponding unbinding rate constants, The binding rate constants are formulated in terms of diffusion-influenced reactions. The theory allows a reconciliation of experimental data on the conductance of the influenza A M2 proton channel with the structure and dynamics of the protein.

引用

页码：1973 / 1976

页数：4

共 48 条

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[32] Fast-Channel Congenital Myasthenic Syndrome (CMS) Caused by Novel AChR ε-Subunit Mutation Subjacent to Agonist Binding Site and Adjacent to the Transmembrane Gating Domain
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[33] TRANSPORT STUDIES OF DOXORUBICIN IN MODEL MEMBRANES INDICATE A DIFFERENCE IN PASSIVE DIFFUSION ACROSS AND BINDING AT THE OUTER AND INNER LEAFLETS OF THE PLASMA-MEMBRANE
SPEELMANS, G
STAFFHORST, RWHM
DEKRUIJFF, B
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ORITO, K
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[37] Light-controlled selective regulators of transmembrane transport of metal ions. Crown either dyes: Structural role of dimer's formation in the ion-binding function
Feofanov, A
Ianoul, A
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Oleinikov, V
Zaitsev, S
Gormov, S
Fedorova, O
Alfimov, M
Nabiev, I
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[38] KINETICS AND ENERGETICS OF AMINE TRANSPORT ACROSS CHARA CELL-MEMBRANE - SELECTIVE, SATURABLE, VOLTAGE-SENSITIVE CHANNEL IN PARALLEL WITH DIFFUSION THROUGH LIPID
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[39] Dual-Site Binding of Quaternary Ammonium Ions as Internal K+-Ion Channel Blockers: Nonclassical (C-H•••O) H Bonding vs Dispersive (C-H•••H-C) Interaction
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[40] TRANSPORT OF POTASSIUM-IONS ACROSS PLANAR LIPID-MEMBRANES BY THE ANTIBIOTIC, GRISORIXIN .1. THE EQUILIBRIUM STATE AND SELF-DIFFUSION K+ FLUXES
AMBLARD, G
SANDEAUX, R
SANDEAUX, J
GAVACH, C
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