Intracranial Venous Alteration in Patients With Aneurysmal Subarachnoid Hemorrhage: Protocol for the Prospective and Observational SAH Multicenter Study (SMS)

被引:2
|
作者
Umana, Giuseppe E. [1 ]
Tomasi, S. Ottavio [2 ,3 ]
Palmisciano, Paolo [1 ]
Scalia, Gianluca [4 ]
Da Ros, Valerio [5 ]
Al-Schameri, Rahman [2 ]
Priola, Stefano M. [6 ]
Brunasso, Lara [7 ]
Giammalva, Giuseppe Roberto [7 ]
Paolini, Federica [7 ]
Costanzo, Roberta [7 ]
Bonosi, Lapo [7 ]
Gerardi, Rosa Maria [7 ]
Maugeri, Rosario [7 ]
Strigari, Lidia [8 ]
Stieg, Philip E. [9 ]
Esposito, Giuseppe [10 ]
Lawton, Michael T. [11 ,12 ]
Griessenauer, Christoph J. [2 ,3 ]
Winkler, Peter A. [2 ]
机构
[1] Cannizzaro Hosp, Trauma Ctr, Gamma Knife Ctr, Dept Neurosurg, Catania, Italy
[2] Paracelsus Med Univ, Dept Neurol Surg, Christian Doppler Klin, Salzburg, Austria
[3] Christian Doppler Klin, Lab Microsurg Neuroanat, Salzburg, Austria
[4] Highly Specialized Hosp Natl Importance Garibaldi, Dept Neurosurg, Catania, Italy
[5] Univ Roma Tor Vergata, Dept Biomed & Prevent, Diagnost Imaging Unit, Rome, Italy
[6] Northern Ontario Sch Med, Div Neurosurg Hlth Sci North, Sudbury, ON, Canada
[7] AOUP Paolo Giaccone, Dept Expt Biomed & Clin Neurosci, Postgrad Residency Programme Neurol Surg, Neurosurg Clin,Sch Med, Palermo, Italy
[8] IRCCS Univ Hosp Bologna, Dept Med Phys, Bologna, Italy
[9] Weill Cornell Med, Dept Neurosurg, New York, NY USA
[10] Univ Zurich, Univ Hosp Zurich, Dept Neurosurg, Zurich, Switzerland
[11] Barrow Neurol Inst, Barrow Aneurysm & AVM Res Ctr, Dept Neurosurg, Phoenix, AZ USA
[12] Barrow Neurol Inst, Barrow Aneurysm & AVM Res Ctr, Dept Neurobiol, Phoenix, AZ USA
来源
FRONTIERS IN SURGERY | 2022年 / 9卷
关键词
brain aneurysm; brain circulation; endovascular coiling; subarachnoid hemorrhage; surgical clipping; vasospasm; venous alteration; DELAYED CEREBRAL-ISCHEMIA; VASCULAR NEURAL-NETWORK; VASOSPASM; NEUROINFLAMMATION; MICROCIRCULATION; EPIDEMIOLOGY; ANGIOGRAPHY; ARTERIES; REGION; VEINS;
D O I
10.3389/fsurg.2022.847429
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background:& nbsp;Arterial vasospasm has been ascribed as the responsible etiology of delayed cerebral infarction in patients with aneurysmal subarachnoid hemorrhage (aSAH), but other neurovascular structures may be involved. We present the protocol for a multicenter, prospective, observational study focused on analyzing morphological changes in cerebral veins of patients with aSAH.Methods and Analysis:& nbsp;In a retrospective arm, we will collect head arterial and venous CT angiograms (CTA) of 50 patients with aSAH and 50 matching healthy controls at days 0-2 and 7-10, comparing morphological venous changes. A multicenter prospective observational study will follow. Patients aged & GE;18 years of any gender with aSAH will be enrolled at 9 participating centers based on the predetermined eligibility criteria. A sample size of 52 aSAH patients is expected, and 52 healthy controls matched per age, gender, and comorbidities will be identified. For each patient, sequential CTA will be conducted upon admission (day 0-2), at 7-10 days, and at 14-21 days after aSAH, evaluating volumes and morphology of the cerebral deep veins and main cortical veins. One specialized image collecting center will analyze all anonymized CTA scans, performing volumetric calculation of targeted veins. Morphological venous changes over time will be evaluated using the Dice coefficient and the Jaccard index and scored using the Boeckh-Behrens system. Morphological venous changes will be correlated to clinical outcomes and compared between patients with aSAH and healthy-controls, and among groups based on surgical/endovascular treatments for aSAH.Ethics and Dissemination:& nbsp;This protocol has been approved by the ethics committee and institutional review board of Ethikkommission, SALK, Salzburg, Austria, and will be approved at all participating sites. The study will comply with the Declaration of Helsinki. Written informed consent will be obtained from all enrolled patients or their legal tutors. We will present our findings at academic conferences and peer-reviewed journals.
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页数:8
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