Neuropeptide Y antibody attenuates 2-deoxy-D-glucose induced feeding in rats

被引：33
|
作者：
He, B [1 ]
White, BD [1 ]
Edwards, GL [1 ]
Martin, RJ [1 ]
机构：
[1] Univ Georgia, Dept Foods & Nutr, Athens, GA 30602 USA
来源：
BRAIN RESEARCH | 1998年 / 781卷 / 1-2期
关键词：
2-deoxy-D-glucose; food intake; neuropeptide Y antibody; paraventricular nucleus;
D O I：
10.1016/S0006-8993(97)01310-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
2-Deoxy-D-glucose (2-DG) has been shown to induce increased feeding responses in animals. Recent studies suggest the possible involvement of neuropeptide Y (NPY) in 2-DG-induced feeding. The present study examined the effect of immunoneutralization of endogenous NPY on 2-DG-induced feeding. NPY antibody injected into the paraventricular nucleus of the rats significantly attenuated 2-DG-induced feeding, suggesting that hypothalamic NPY may mediate, at least partly, the effect of 2-DG on food intake. (C) 1998 Elsevier Science B.V.
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页码：348 / 350
页数：3
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