Cryopreservation of testicular tissue in children

被引：7

作者：

Rives, Nathalie ^{[1
,2
]}

Milazzo, Jean-Pierre ^{[1
,2
]}

Travers, Albanne ^{[1
,2
]}

Arkoun, Brahim ^{[1
,2
]}

Bironneau, Amandine ^{[1
,2
]}

Sibert, Louis ^{[2
,3
]}

Liard-Zmuda, Agnes ^{[2
,4
]}

Marie-Cardine, Aude ^{[2
,4
]}

Schneider, Pascale ^{[2
,4
]}

Vannier, Jean-Pierre ^{[2
,4
]}

Mace, Bertrand ^{[1
,2
]}

机构：

[1] CHU Charles Nicolle, CHU Hop Rouen, EA Gametogenese & Qualite Gamete 4308, Lab Biol Reprod,CECOS,IRIB, F-76031 Rouen, France

[2] Univ Rouen, F-76821 Mont St Aignan, France

[3] CHU Charles Nicolle, CHU Hop Rouen, EA Gametogenese & Qualite Gamete 4308, IRIB, F-76031 Rouen, France

[4] CHU Charles Nicolle, CHU Hop Rouen, F-76031 Rouen, France

来源：

BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE | 2013年 / 197卷 / 4-5期

关键词：

NEOPLASMS; CHILD; FERTILITY PRESERVATION; TESTICULAR NEOPLASMS; SPERMATOGONIAL STEM-CELLS; FERTILITY PRESERVATION; CHILDHOOD-CANCER; ADOLESCENT CANCER; PREPUBERTAL BOYS; TRANSPLANTATION; EXPERIENCE; SURVIVAL; RISK; SPERMATOGENESIS;

D O I：

10.1016/S0001-4079(19)31531-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The toxicity of cancer therapies can affect all organs and tissues. Some treatments damage spermatogonial stem cells (SSCs), with a risk of infertility. Storage and reimplantation of frozen testicular tissue is a recent approach to fertility preservation for young boys. However; thawed frozen prepubertal testicular tissue must undergo a maturation process to restore sperm production. This process, currently being studied in animal models, can be achieved by in vivo transplantation of SSCs into seminiferous tubules or by testicular grafting, possibly following in vitro maturation.

引用

页码：877 / 886

页数：10

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