Visible-light induced Cross-Dehydrogenative-Coupling (CDC) reactions of N-aryl tetrahydroisoquinolines under aerobic conditions

被引：10
|
作者：
Lin, Chao [1 ]
Li, Peiwu [1 ]
Wang, Lin [2 ]
机构：
[1] Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
[2] Yantai Univ, Key Lab Mol Pharmacol & Drug Evaluat, Minist Educ, Yantai 264005, Peoples R China
来源：
TETRAHEDRON LETTERS | 2021年 / 73卷
关键词：
Cross-dehydrogenative-coupling; N-aryl tetrahydroisoquinolines; Oxygen; SP(3) C-H; CATALYZED OXIDATIVE CYANATION; TERTIARY-AMINES; BOND FUNCTIONALIZATION; MOLECULAR-OXYGEN; MANNICH REACTION; EFFICIENT; ACTIVATION; ADJACENT; COMPLEXES;
D O I：
10.1016/j.tetlet.2021.153102
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A visible-light induced cross-dehydrogenative-coupling (CDC) reaction of N-aryl tetrahydroisoquinolines was developed under mild aerobic conditions. This protocol proceeded smoothly with a large range of nucleophiles (nitroalkane, dimethyl phosphite, dimethyl malonate, N-methyl indole, TMSCN) under metal-free conditions and an oxygen atmosphere, forming a new CAC bond. Visible-light played a significant acceleration effect in this reaction. (C) 2021 Elsevier Ltd. All rights reserved.
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页数：4
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