Enantioselective addition of Et2Zn to aldehydes catalyzed by chiral aliphatic β-amino alcohols

被引：0

作者：

Shen, ZX ^{[1
]}

Xu, XN ^{[1
]}

Liu, XF ^{[1
]}

Zhang, LF ^{[1
]}

Zhang, YW ^{[1
]}

机构：

[1] Suzhou Univ, Dept Chem & Chem Engn, Suzhou 215006, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2000年 / 18卷 / 04期

关键词：

enantioselective addition; beta-amino alcohol; enantioselectivity;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This paper describes the preparation of two new optically active aliphatic beta-amino alcohols (R)-5,5-dimethyl-2(dimethylamino)-1,1-diphenyl-1-hexanol (1a) and (S)-8,8-dimethyl-2-(dimethylamino)-1,1-diphenyl-1-nonanol (Ib). They were synthesized by methylation of the corresponding beta-amino alcohols 2a and 2b. Compounds la and Ib catalyze the addition of diethylzinc to various aldehydes enantioselectively. The catalyst structure-enantioselectivity relationships were discussed.

引用

页码：582 / 584

页数：3

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