Anti-leishmania activity of semi-purified fraction of Jacaranda puberula leaves

被引：14
|
作者：
Passero, L. F. D.
Castro, A. A.
Tomokane, T. Y.
Kato, M. J.
Paulinetti, T. F.
Corbett, C. E. P.
Laurenti, M. D.
机构：
[1] Univ Sao Paulo, Dept Patol, Fac Med, BR-0146903 Sao Paulo, Brazil
[2] Univ Sao Paulo, Dept Bioquim, Inst Quim, BR-05508000 Sao Paulo, Brazil
来源：
PARASITOLOGY RESEARCH | 2007年 / 101卷 / 03期
关键词：
IMMUNE-RESPONSE; RESISTANCE; MECHANISMS; INFECTION; PLANTS;
D O I：
10.1007/s00436-007-0530-y
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The crude methanolic extract from leaves of Jacaranda puberula showed activity against Leishmania (Leishmania) amazonensis. The extract presented active against promastigote forms with an inhibitory concentration 50% (IC50) value of 88.0 mu g/ml, but only moderated activity against amastigote forms; however in higher concentrations the extract showed cytotoxic effects. The bio-guided chromatographic fractionation the crude methanolic extract against amastigotes yielded a fraction with an IC50 value of 14.0 mu g/ml (without cytotoxic activity) in relation to the crude extract (IC50 value, 359.0 mu g/ml). These data indicate that J. puberula leaves contain active compounds, which should be further investigated for the development of new potential drugs against cutaneous leishmaniasis.
引用
收藏
页码：677 / 680
页数：4
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