Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis

被引：148

作者：

Alangaden, GJ

Kreiswirth, BN

Aouad, A

Khetarpal, M

Igno, FR

Moghazeh, SL

Manavathu, EK

Lerner, SA

机构：

[1] Wayne State Univ, Sch Med, Div Infect Dis, Detroit, MI 48201 USA

[2] Wayne State Univ, Sch Med, Dept Biochem & Mol Biol, Detroit, MI 48201 USA

[3] Publ Hlth Res Inst City New York Inc, TB Ctr, New York, NY 10016 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 05期

关键词：

D O I：

10.1128/AAC.42.5.1295

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An A1400G mutation of the ns gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 mu g/ml). High-level cross-resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and lower levels of resistance in four clinical isolates, all lacking the A1400G mutation.

引用

页码：1295 / 1297

页数：3

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