Pegfilgrastim in Children With Severe Congenital Neutropenia

被引：10

作者：

Fioredda, Francesca ^{[1
]}

Calvillo, Michaela

Lanciotti, Marina

Lanza, Tiziana

Giunti, Laura ^{[2
]}

Castagnola, Elio ^{[3
]}

Lorenzi, Ines ^{[4
]}

Tonelli, Rossella ^{[5
]}

Ghezzi, Piero ^{[5
]}

Dufour, Carlo

机构：

[1] Giannina Gaslini Childrens Hosp, Dept Pediat Hematol Oncol & Bone Marrow Transplan, Haematol Unit, I-16147 Genoa, Italy

[2] Meyer Hosp, Dept Pediat, Med Genet Unit, Florence, Italy

[3] Giannina Gaslini Childrens Hosp, Infect Dis Unit, I-16147 Genoa, Italy

[4] Giannina Gaslini Childrens Hosp, Dept Pharm, I-16147 Genoa, Italy

[5] Mario Negri Inst Pharmacol Res, Lab Neuroimmunol, Milan, Italy

来源：

PEDIATRIC BLOOD & CANCER | 2010年 / 54卷 / 03期

关键词：

filgrastim; pegfilgrastim; r-Hu-granulocyte-stimulating factor; severe congenital neutropenia; G-CSF; FILGRASTIM;

D O I：

10.1002/pbc.22350

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Two pediatric patients affected by severe congenital neutropenia (SCN) were treated with 100 mcg/L/dose every 9-12 clays within a Pilot Study (Observatory of the Italian Ministry of Health, Eudract Code 2005-003096-20) on the use of pegfilgrastim in patients with chronic neutropenia. Both children increased their absolute neutrophil Count, reduced their infectious load, and improved their quality of life. Serum concentrations of G-CSF observed in pegfilgrastim mirrored those seen in filgrastim. These data Suggest that pegfilgrastim may be beneficial in SCN patients with an exposure of hematopoietic cells to G-CSF similar to that on filgrastim. Pediatr Blood Cancer 2010;54:465-467. (C) 2009 Wiley-Liss, Inc.

引用

页码：465 / 467

页数：3

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