Metal-free synthesis of sulfonylated amides through radical aryl migration-desulfonylation

被引：22
|
作者：
Qiu, Jiang-Kai [1 ,2 ,3 ]
Hao, Wen-Juan [1 ,2 ]
Kong, Li-Fang [4 ]
Ping, Wei [3 ]
Tu, Shu-Jiang [1 ,2 ]
Jiang, Bo [1 ,2 ]
机构：
[1] Jiangsu Normal Univ, Sch Chem & Chem Engn, Xuzhou 221116, Peoples R China
[2] Jiangsu Normal Univ, Jiangsu Key Lab Green Synthet Chem Funct Mat, Xuzhou 221116, Peoples R China
[3] Nanjing Tech Univ, Biotechnol & Pharmaceut Engn, Nanjing 210009, Jiangsu, Peoples R China
[4] Air Force Logist Acad, Dept Basic Teaching, Xuzhou, Jiangsu, Peoples R China
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 22期
基金：
中国国家自然科学基金;
关键词：
Desulfonylation; Metal-free synthesis; Sulfonylated amides; CATALYZED ARYLSULFONYLATION; ACTIVATED ALKENES; BOND FORMATION; SULFONES;
D O I：
10.1016/j.tetlet.2016.04.073
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A metal-free arylsulfonyl radical-triggered desulfonylation of N-aryl-N-arylsulfonyl-acrylamides under mild conditions for the facile synthesis of a series of sulfonylated amides has been described. The radical transformation simultaneously installs C-S and C-C bonds with concomitant cleavage of N-S and C-S bonds through continuous 5-exo-trig cyclization, desulfonylation, and aryl migration sequence. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2414 / 2417
页数：4
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