Metal-Free Mediated Meerwein-Type Reaction: A Radical Cascade Arylation/Aryl Migration/Desulfonylation of Conjugated Alkenes

被引：33
|
作者：
Ni, Zhangqin [1 ]
Huang, Xin [1 ]
Pan, Yuanjiang [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 11期
基金：
中国国家自然科学基金;
关键词：
C-H ARYLATION; NITROSATED IN-SITU; ACTIVATED ALKENES; DIAZONIUM SALTS; SANDMEYER TRIFLUOROMETHYLATION; INTRAMOLECULAR DIAMINATION; ARENEDIAZONIUM SALTS; UNACTIVATED ALKENES; AQUEOUS-MEDIA; ARYL;
D O I：
10.1021/acs.orglett.6b01041
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A metal-free cascade arylation/aryl migration/desulfonylation of N-phenyl-N-(phenylsulfonyl)methacrylamide is described. The in situ generated diazonium salts from anilines and t-BuONO are used as aryl precursors. This process provides an efficient strategy for the synthesis of alpha-all-carbon quaternary stereocenters amides. A radical mechanism was proposed for this transformation.
引用
收藏
页码：2612 / 2615
页数：4
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